Skip to main content

Lacticaseibacillus casei ATCC334 Ameliorates Radiation-Induced Intestinal Injury in Rats by Targeting Microbes and Metabolites.

  • 2022-11-21
  • Molecular Nutrition & Food Research 67(1)
    • Qinglian Hua
    • Haowen Zhang
    • R. Xu
    • Chunxiang Tian
    • Tianlin Gao
    • Yanquan Yuan
    • Yaling Han
    • Yue Li
    • Ce Qi
    • Feng Zhong
    • Aiguo Ma


Scope: Gastrointestinal side effects are frequently observed in patients receiving medical radiation therapy. As Lacticaseibacillus casei ATCC334 potentially affects microbial ecosystem, the study hypothesizes that it may improve radiation-induced intestinal injury in rats by modulating the "gut microbiota-metabolite-barrier axis."

Methods and results: Rats are fed one of three or no doses of L. casei ATCC334 for 7 days and then expose to a single dose of 9 Gy X-ray total abdominal irradiation. Supplementation with L. casei ATCC334 promote the proliferation of intestinal stem cells (ISCs), increase the expression of tight junction proteins, reduce intestinal permeability, and protect intestinal barrier integrity. Moreover, 16S rRNA sequencing show that medium and high doses of L. casei ATCC334 inhibit the growth of Escherichia/Shigella and favor Akkermansia proliferation. L. casei ATCC334 intervention reprogram the metabolic profile and inhibit putrescine production but promote alpha-linolenic acid (ALA) production. Notably, a decrease in putrescine and an increase in ALA are significantly correlated with the proliferation of ISCs and enhanced intestinal barrier function following L. casei ATCC334 intervention.

Conclusion: These results highlight that medium and high doses of L. casei ATCC334 alleviate radiation-induced intestinal damage by enhancing the mucosal barrier and remodeling the gut microbiota structure and metabolic activity.

Keywords: Lacticaseibacillus casei ATCC334; alpha-linolenic acid; gut microbiota; putrescine; radiation-induced intestinal injury.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lacticaseibacillus caseiAltered Metabolic ProfileBeneficial
Lacticaseibacillus caseiImproved Intestinal Barrier FunctionBeneficial
Lacticaseibacillus caseiReduced Pathogen GrowthBeneficial
Lacticaseibacillus casei R0215Improved Intestinal Barrier FunctionBeneficial
Lacticaseibacillus casei R0215Improved Metabolic HealthBeneficial
Lacticaseibacillus casei R0215Reduced Harmful Gut MicrobiotaBeneficial

Pillser helps you make informed health decisions by providing comprehensive, unbiased information about supplements. This includes detailed research on supplement ingredients, their benefits, potential risks, and their overall efficacy. You can contribute by sharing your feedback and suggestions.

Send us an email at