Lacticaseibacillus rhamnosus GR-1, a.k.a. Lactobacillus rhamnosus GR-1: Past and Future Perspectives.
- 2021-08
- Trends in Microbiology 29(8)
- M. Petrova
- G. Reid
- Jessica A. ter Haar
- PubMed: 33865678
- DOI: 10.1016/j.tim.2021.03.010
Abstract
Lacticaseibacillus rhamnosus GR-1 (LGR-1) (previously classified as Lactobacillus rhamnosus GR-1) is the most researched probiotic strain for women's health. Its various urogenital health effects, including a reduction in the recurrence of bacterial vaginosis and urinary-tract infection, are well documented. The strain has also been safely used by HIV-positive subjects, a portion of whom have reported reduced diarrhea and increased CD4 counts. Unlike most probiotic strains used for urogenital health, LGR-1 has been extensively studied for its properties, including its genomic and metabolic traits and its surface properties. This review aims to highlight the totality of research performed with LGR-1, to act as a rigorous scientific benchmark for probiotic microbes, especially for application to women's health.
Keywords: Lacticaseibacillus; Lactobacillus; STIs; bacterial vaginosis; host–microbe interaction; probiotics; urinary-tract infections; vaginal microbiota.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lacticaseibacillus rhamnosus | Increased CD4+ T Cell Count | Beneficial | Moderate |
| Lacticaseibacillus rhamnosus | Reduced Diarrhea Rate | Beneficial | Moderate |
| Lacticaseibacillus rhamnosus | Reduced Recurrence of Bacterial Vaginosis | Beneficial | Moderate |
| Lacticaseibacillus rhamnosus | Reduced Recurrence of Urinary Tract Infections | Beneficial | Moderate |
| Lactobacillus rhamnosus | Increased CD4+ T Cell Count | Beneficial | Moderate |
| Lactobacillus rhamnosus | Reduced Diarrhea Rate | Beneficial | Moderate |
| Lactobacillus rhamnosus | Reduced Recurrence of Bacterial Vaginosis | Beneficial | Moderate |
| Lactobacillus rhamnosus | Reduced Recurrence of Urinary Tract Infections | Beneficial | Moderate |
| Lactobacillus rhamnosus DSM 6594 | Increased CD4 Counts | Beneficial | Small |
| Lactobacillus rhamnosus DSM 6594 | Reduced Diarrhea in HIV-Positive Subjects | Beneficial | Small |
| Lactobacillus rhamnosus DSM 6594 | Reduced Recurrence of Bacterial Vaginosis | Beneficial | Moderate |
| Lactobacillus rhamnosus DSM 6594 | Reduced Recurrence of Urinary Tract Infections | Beneficial | Moderate |
| Lactobacillus rhamnosus DSM33560 | Increased CD4 Counts | Beneficial | Small |
| Lactobacillus rhamnosus DSM33560 | Reduced Diarrhea in HIV-Positive Subjects | Beneficial | Small |
| Lactobacillus rhamnosus DSM33560 | Reduced Recurrence of Bacterial Vaginosis | Beneficial | Moderate |
| Lactobacillus rhamnosus DSM33560 | Reduced Recurrence of Urinary Tract Infections | Beneficial | Moderate |
| Lactobacillus rhamnosus GR-1 | Increased CD4 Counts | Beneficial | Small |
| Lactobacillus rhamnosus GR-1 | Reduced Diarrhea in HIV-Positive Subjects | Beneficial | Small |
| Lactobacillus rhamnosus GR-1 | Reduced Recurrence of Bacterial Vaginosis | Beneficial | Moderate |
| Lactobacillus rhamnosus GR-1 | Reduced Recurrence of Urinary Tract Infections | Beneficial | Moderate |
| Lactobacillus rhamnosus HA-111 | Increased CD4+ T Cell Count | Beneficial | Moderate |
| Lactobacillus rhamnosus HA-111 | Reduced Diarrhea Rate | Beneficial | Moderate |
| Lactobacillus rhamnosus HA-111 | Reduced Recurrence of Bacterial Vaginosis | Beneficial | Moderate |
| Lactobacillus rhamnosus HA-111 | Reduced Recurrence of Urinary Tract Infections | Beneficial | Moderate |
| Lactobacillus rhamnosus LR06 | Increased CD4 Counts | Beneficial | Small |
| Lactobacillus rhamnosus LR06 | Reduced Diarrhea in HIV-Positive Subjects | Beneficial | Small |
| Lactobacillus rhamnosus LR06 | Reduced Recurrence of Bacterial Vaginosis | Beneficial | Moderate |
| Lactobacillus rhamnosus LR06 | Reduced Recurrence of Urinary Tract Infections | Beneficial | Moderate |
| Lactobacillus rhamnosus lysate powder | Improved Health in HIV-Positive Subjects | Beneficial | Moderate |
| Lactobacillus rhamnosus R0011 | Increased CD4+ T Cell Count | Beneficial | Moderate |
| Lactobacillus rhamnosus R0011 | Reduced Diarrhea Symptoms in HIV-Positive Subjects | Beneficial | Moderate |
| Lactobacillus rhamnosus R0011 | Reduced Recurrence of Bacterial Vaginosis | Beneficial | Moderate |
| Lactobacillus rhamnosus R0011 | Reduced Recurrence of Urinary Tract Infections | Beneficial | Moderate |
| Lactobacillus rhamnosus R0343ND | Increased CD4 Counts | Beneficial | Small |
| Lactobacillus rhamnosus R0343ND | Reduced Diarrhea in HIV-Positive Subjects | Beneficial | Small |
| Lactobacillus rhamnosus R0343ND | Reduced Recurrence of Bacterial Vaginosis | Beneficial | Moderate |
| Lactobacillus rhamnosus R0343ND | Reduced Recurrence of Urinary Tract Infections | Beneficial | Moderate |
| Lactobacillus rhamnosus UALr-18 | Increased CD4 Counts | Beneficial | Small |
| Lactobacillus rhamnosus UALr-18 | Reduced Diarrhea in HIV-Positive Subjects | Beneficial | Small |
| Lactobacillus rhamnosus UALr-18 | Reduced Recurrence of Bacterial Vaginosis | Beneficial | Moderate |
| Lactobacillus rhamnosus UALr-18 | Reduced Recurrence of Urinary Tract Infections | Beneficial | Moderate |