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Lactiplantibacillus plantarum AR113 Exhibit Accelerated Liver Regeneration by Regulating Gut Microbiota and Plasma Glycerophospholipid

  • 2022-01-13
  • Frontiers in Microbiology 12
    • C. Xie
    • Zhoumei Zhang
    • Manyi Yang
    • Changliang Cao
    • Yingjun Zhou
    • Zuohua Zhu
    • Wenbing Gong
    • Chao Xu
    • Li Yan
    • Zhenxiu Hu
    • Lian-zhong Ai
    • Yuande Peng

Abstract

Emerging evidence indicates that probiotics have been proved to influence liver injury and regeneration. In the present study, the effects of Lactiplantibacillus plantarum AR113 on the liver regeneration were investigated in 70% partial hepatectomy (PHx) rats. Sprague-Dawley (SD) rats were gavaged with L. plantarum AR113 suspensions (1 × 1010 CFU/mL) both before and after partial hepatectomy. The results showed that L. plantarum AR113 administration 2 weeks before partial hepatectomy can accelerate liver regeneration by increased hepatocyte proliferation and tumor necrosis factor-α (TNF-α), hepatocyte growth factor (HGF), and transforming growth factor-β (TGF-β) expression. Probiotic administration enriched Lactobacillus and Bacteroides and depleted Flavonifractor and Acetatifactor in the gut microbiome. Meanwhile, L. plantarum AR113 showed decline of phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidyl serine (PS), and lysophosphatidyl choline (LysoPC) levels in the serum of the rats after the L. plantarum AR113 administration. Moreover, L. plantarum AR113 treated rats exhibited higher concentrations of L-leucine, L-isoleucine, mevalonic acid, and lower 7-oxo-8-amino-nonanoic acid in plasma than that in PHx. Spearman correlation analysis revealed a significant correlation between changes in gut microbiota composition and glycerophospholipid. These results indicate that L. plantarum AR113 is promising for accelerating liver regeneration and provide new insights regarding the correlations among the microbiome, the metabolome, and liver regeneration.

Keywords: Lactiplantibacillus plantarum; glycerophospholipid; gut microbiota; liver regeneration; partial hepatectomy; plasma metabolites.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactiplantibacillus plantarumAltered Gut MicrobiotaBeneficial
Moderate
Lactiplantibacillus plantarumAltered Plasma Metabolite LevelsBeneficial
Moderate
Lactiplantibacillus plantarumImproved Liver RegenerationBeneficial
Large
Lactiplantibacillus plantarumReduced Serum Glycerophospholipid LevelsBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-023Changed Plasma Glycerophospholipid LevelsNeutral
Moderate
Lactiplantibacillus plantarum KABP™-023Improved Gut Microbiome CompositionBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-023Improved Liver RegenerationBeneficial
Large
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