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Abstract

Previous studies have found that probiotic supplements can ameliorate mental behavioral disorders. This study investigated the effects of Lactiplantibacillus plantarum DMDL 9010 (LP9010) intake on the depression-like behavior induced by dextran sodium sulfate (DSS) and its possible mechanism. Male C57BL/6N mice were fed with DSS to establish the model of ulcerative colitis. LP9010 intake reduced the DSS-induced inflammatory response, and repaired intestinal barrier damage, as well as lightened depression-like behavior. LP9010 supplementation also inhibited neuroinflammation by up-regulating the levels of neurotransmitters, especially 5-HT, NE, DA, and 5-HIAA. Moreover, the intake of LP9010 reorganized the gut microbiome by increasing the relative abundance of Bacteroidetes and Firmicutes, and decreasing the relative abundance of Proteobacteria and Verrucomicrobia. Furthermore, treatment with LP9010 increased the levels of short-chain fatty acids, such as butyric acid and propionic acid. In conclusion, LP9010 intake was a promising probiotic intervention strategy for the prevention of colitis-induced behavioral disorders through the microbiota-gut-brain axis.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactiplantibacillus plantarum LP-1Enhanced Beneficial Gut MicrobiotaBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Improved Intestinal Barrier FunctionBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Increased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced Depression-like BehaviorBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced Inflammatory ResponseBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced NeuroinflammationBeneficial
Moderate

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