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Lactiplantibacillus plantarum WJL administration during pregnancy and lactation improves lipid profile, insulin sensitivity and gut microbiota diversity in dyslipidemic dams and protects male offspring against cardiovascular dysfunction in later life.

  • 2020
  • Food & Function 11(10)
    • K. Guimarães
    • V. Braga
    • S. Noronha
    • Whyara K A Costa
    • Kassem Makki
    • J. Cruz
    • Larissa Ramalho Brandão
    • Deoclecio Alves Chianca Junior
    • E. Meugnier
    • F. Leulier
    • H. Vidal
    • M. Magnani
    • J. L. de Brito Alves

Abstract

Background and aim: Maternal dyslipidemia is recognized as a risk factor for the development of arterial hypertension (AH) and cardiovascular dysfunction in offspring. Here we evaluated the effects of probiotic administration of a specific strain of Lactiplantibacillus plantarum (WJL) during pregnancy and lactation on gut microbiota and metabolic profile in dams fed with a high-fat and high-cholesterol (HFHC) diet and its long-term effects on the cardiovascular function in male rat offspring.

Methods and results: Pregnant Wistar rats were allocated into three groups: dams fed a control diet (CTL = 5), dams fed a HFHC diet (DLP = 5) and dams fed a HFHC diet and receiving L. plantarum WJL during pregnancy and lactation (DLP-LpWJL). L. plantarum WJL (1 × 109 CFU) or vehicle (NaCl, 0.9%) was administered daily by oral gavage for 6 weeks, covering the pregnancy and lactation periods. After weaning, male offspring received a standard diet up to 90 days of life. Biochemical measurements and gut microbiota were evaluated in dams. In male offspring, blood pressure (BP), heart rate (HR) and vascular reactivity were evaluated at 90 days of age. Dams fed with a HFHC diet during pregnancy and lactation had increased lipid profile and insulin resistance and showed dysbiotic gut microbiota. Administration of L. plantarum WJL to dams having maternal dyslipidemia improved gut microbiota composition, lipid profile and insulin resistance in them. Blood pressure was augmented and vascular reactivity was impaired with a higher contractile response and a lower response to endothelium-dependent vasorelaxation in DLP male offspring. In contrast, male offspring of DLP-LpWJL dams had reduced blood pressure and recovered vascular function in later life.

Conclusion: Administration of L. plantarum WJL during pregnancy and lactation in dams improved gut microbiota diversity, reduced maternal dyslipidemia and prevented cardiovascular dysfunction in male rat offspring.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactiplantibacillus plantarumImproved Gut Microbiota DiversityBeneficial
Moderate
Lactiplantibacillus plantarumImproved Insulin SensitivityBeneficial
Moderate
Lactiplantibacillus plantarumImproved Lipid ProfileBeneficial
Moderate
Lactiplantibacillus plantarumImproved Vascular FunctionBeneficial
Moderate
Lactiplantibacillus plantarumReduced Blood PressureBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-022Improved Gut Microbiota DiversityBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-022Improved Insulin SensitivityBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-022Improved Lipid ProfileBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-022Improved Vascular Function in OffspringBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-022Reduced Blood Pressure in OffspringBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-023Improved Gut Microbiota DiversityBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-023Improved Insulin SensitivityBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-023Improved Lipid ProfileBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-023Improved Vascular FunctionBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-023Reduced Blood PressureBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-023Reduced Cardiovascular DysfunctionBeneficial
Large
Lactiplantibacillus plantarum LP-01Improved Gut Microbiota DiversityBeneficial
Moderate
Lactiplantibacillus plantarum LP-01Improved Insulin SensitivityBeneficial
Moderate
Lactiplantibacillus plantarum LP-01Improved Lipid ProfileBeneficial
Moderate
Lactiplantibacillus plantarum LP-01Improved Vascular FunctionBeneficial
Moderate
Lactiplantibacillus plantarum LP-01Reduced Blood Pressure in OffspringBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Improved Gut Microbiota DiversityBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Improved Insulin SensitivityBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Improved Lipid ProfileBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Improved Vascular FunctionBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced Blood Pressure in OffspringBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Improved Gut Microbiota DiversityBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Improved Insulin SensitivityBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Improved Lipid ProfileBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Improved Vascular FunctionBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Reduced Blood Pressure in OffspringBeneficial
Moderate

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