Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial
- 2020-01-30
- Nutrients 12(2)
- C. Martoni
- S. Srivastava
- G. Leyer
- PubMed: 32019158
- DOI: 10.3390/nu12020363
Study Design
- Type
- Randomized Controlled Trial (RCT)
- Sample size
- n = 330
- Population
- Adults with IBS
- Methods
- Randomized Controlled Trial
- Large Human Trial
Abstract
This randomized, double-blind, placebo-controlled, multi-center study investigated the clinical efficacy of two probiotic strains on abdominal pain severity and symptomology in irritable bowel syndrome (IBS). Three hundred and thirty adults, aged 18 to 70 years, with IBS according to Rome IV criteria were allocated (1:1:1) to receive placebo, L__actobacillus acidophilus DDS-1 (1 × 1010 CFU/day) or B__ifidobacterium animalis subsp. lactis UABla-12 (1 × 1010 CFU/day) over six weeks. The primary outcome was the change in Abdominal Pain Severity - Numeric Rating Scale (APS-NRS). Over the intervention period, APS-NRS was significantly improved in both probiotic groups vs. placebo in absolute terms (DDS-1: -2.59 ± 2.07, p = 0.001; UABla-12: -1.56 ± 1.83, p = 0.001) and in percentage of significant responders (DDS-1: 52.3%, p < 0.001); UABla-12 (28.2%, p = 0.031). Significant amelioration vs. placebo was observed in IBS Symptom Severity Scale (IBS-SSS) scores for L. acidophilus DDS-1 (-133.4 ± 95.19, p < 0.001) and B. lactis UABla-12 (-104.5 ± 96.08, p < 0.001) groups, including sub-scores related to abdominal pain, abdominal distension, bowel habits and quality of life. Additionally, a significant normalization was observed in stool consistency in both probiotic groups over time and as compared to placebo. In conclusion, L. acidophilus DDS-1 and B. lactis UABla-12 improved abdominal pain and symptom severity scores with a corresponding normalization of bowel habits in adults with IBS.
Keywords: Randomized controlled trial; abdominal pain; bowel habits; irritable bowel syndrome; microbiome; probiotic.
Research Insights
Additionally, a significant normalization was observed in stool consistency in both probiotic groups over time and as compared to placebo.
- Effect
- Beneficial
- Effect size
- Moderate
APS-NRS was significantly improved in both probiotic groups vs. placebo in absolute terms (DDS-1: -2.59 ± 2.07, p = 0.001; UABla-12: -1.56 ± 1.83, p = 0.001)
- Effect
- Beneficial
- Effect size
- Moderate
Significant amelioration vs. placebo was observed in IBS Symptom Severity Scale (IBS-SSS) scores for ... B. lactis UABla-12 (-104.5 ± 96.08, p < 0.001)
- Effect
- Beneficial
- Effect size
- Moderate
Additionally, a significant normalization was observed in stool consistency in both probiotic groups over time and as compared to placebo.
- Effect
- Beneficial
- Effect size
- Moderate
- Dose
- 1 × 10^10 CFU/day
Significant amelioration vs. placebo was observed in IBS Symptom Severity Scale (IBS-SSS) scores for ... B. lactis UABla-12 (-104.5 ± 96.08, p < 0.001)
- Effect
- Beneficial
- Effect size
- Moderate
- Dose
- 1 × 10^10 CFU/day
Over the intervention period, APS-NRS was significantly improved in both probiotic groups vs. placebo in absolute terms (DDS-1: -2.59 ± 2.07, p = 0.001; UABla-12: -1.56 ± 1.83, p = 0.001) and in percentage of significant responders (DDS-1: 52.3%, p < 0.001); UABla-12 (28.2%, p = 0.031).
- Effect
- Beneficial
- Effect size
- Large
Additionally, a significant normalization was observed in stool consistency in both probiotic groups over time and as compared to placebo.
- Effect
- Beneficial
- Effect size
- Moderate
Significant amelioration vs. placebo was observed in IBS Symptom Severity Scale (IBS-SSS) scores for L. acidophilus DDS-1 (-133.4 ± 95.19, p < 0.001) and B. lactis UABla-12 (-104.5 ± 96.08, p < 0.001) groups, including sub-scores related to abdominal pain, abdominal distension, bowel habits and quality of life.
- Effect
- Beneficial
- Effect size
- Large