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Abstract

Four human Lactobacillus acidophilus strains were tested for their ability to adhere onto human enterocyte like Caco-2 cells in culture. The LA 1 strain exhibited a high calcium independent adhesive property. This adhesion onto Caco-2 cells required a proteinaceous adhesion promoting factor, which was present in the spent bacterial broth culture supernatant. LA 1 strain also strongly bound to the mucus secreted by the homogeneous cultured human goblet cell line HT29-MTX. The inhibitory effect of LA 1 organisms against Caco-2 cell adhesion and cell invasion by a large variety of diarrhoeagenic bacteria was investigated. As a result, the following dose dependent inhibitions were obtained: (a) against the cell association of enterotoxigenic, diffusely adhering and enteropathogenic Escherichia coli, and Salmonella typhimurium; (b) against the cell invasion by enteropathogenic Escherichia coli, Yersinia pseudotuberculosis, and Salmonella typhimurium. Incubations of L acidophilus LA 1 before and together with enterovirulent E coli were more effective than incubation after infection by E coli.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus acidophilus LA-02Binding to Goblet Cell MucusBeneficial
Large
Lactobacillus acidophilus LA-02Reduced Adhesion to Human Intestinal CellsBeneficial
Large
Lactobacillus acidophilus LA1Reduced Enterotoxigenic E. coli AdhesionBeneficial
Moderate
Lactobacillus acidophilus LA1Reduced Pathogen AdhesionBeneficial
Moderate
Lactobacillus acidophilus LA1Reduced Pathogenic Bacterial InvasionBeneficial
Moderate
Lactobacillus acidophilus LA1Reduced Salmonella typhimurium AdhesionBeneficial
Moderate
Lactobacillus acidophilus LA1Reduced Yersinia Pseudotuberculosis InvasionBeneficial
Moderate
Lactobacillus acidophilus La-14Improved Mucus BindingBeneficial
Large
Lactobacillus acidophilus La-14Increased Intestinal Cell AdhesionBeneficial
Large
Lactobacillus acidophilus LA-5Improved Gut HealthBeneficial
Moderate
Lactobacillus acidophilus LA-5Reduced Incidence of Bacterial InfectionsBeneficial
Moderate
Lactobacillus acidophilus LA-5Reduced Pathogen AdhesionBeneficial
Moderate
Lactobacillus acidophilus R0418Reduced Cell Attachment due to Enterovirulent BacteriaBeneficial
Large
Lactobacillus acidophilus R0418Reduced Cellular Invasion by Enterovirulent BacteriaBeneficial
Large
Lactobacillus acidophilus UALa01Reduced Adhesion of Diarrheagenic BacteriaBeneficial
Moderate
Lactobacillus acidophilus UALa01Reduced Pathogenic Bacterial InvasionBeneficial
Moderate

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