Skip to main content

Abstract

Lactobacillus acidophilus, as the main probiotic in the small intestine, has a role in modulating intestinal immune activity; however, its potential molecular regulatory mechanisms have rarely been investigated. To investigate the effects of Lactobacillus acidophilus LA85 in immunoprophylaxis, LA85 at the dose of 1 × 108 CFU mL-1, 1 × 109 CFU mL-1, and 1 × 1010 CFU mL-1 were orally administered to immunocompromised ICR mice that had been treated intraperitoneally with 80 mg kg-1 cyclophosphamide. The experimental results showed that LA85 could regulate the Notch signaling pathway and promote intestinal mucosal repair. And it could enhance the immune response of the body through the TLR4/NF-κB signaling pathway. 16S rDNA gene sequencing revealed that LA85 reduced the ratio of Firmicutes/Bacteroidetes and reshaped the gut microbiota. Furthermore, we discovered the correlation between Erysipelatoclostridium, Rikenella, and the intestinal Notch signaling pathway, and further discovered the potential mechanism of LA85 in intestinal mucosal repair. Based on the results of the study, we found that the effect of high doses of LA85 was more significant. Therefore, LA85 can be used as a dietary supplement to potentially enhance the immune capacity of patients.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus acidophilusAltered Gut MicrobiotaBeneficial
Moderate
Lactobacillus acidophilusImproved Immune ResponseBeneficial
Large
Lactobacillus acidophilusImproved Intestinal Mucosal RepairBeneficial
Large
Lactobacillus acidophilus HA-122Improved Immune ResponseBeneficial
Large
Lactobacillus acidophilus HA-122Improved Intestinal Mucosal RepairBeneficial
Large
Lactobacillus acidophilus HA-122Modulated Gut MicrobiotaBeneficial
Large
Lactobacillus acidophilus LA-02Improved Cyclophosphamide-Induced ImmunosuppressionBeneficial
Large
Lactobacillus acidophilus LA-02Improved Immune ResponseBeneficial
Large
Lactobacillus acidophilus LA-02Improved Intestinal Mucosal RepairBeneficial
Large
Lactobacillus acidophilus LA-02Normalized Gut MicrobiotaBeneficial
Moderate
Lactobacillus acidophilus LA1Altered Gut MicrobiotaBeneficial
Moderate
Lactobacillus acidophilus LA1Improved Immune ResponseBeneficial
Large
Lactobacillus acidophilus LA1Improved Intestinal Mucosal RepairBeneficial
Large
Lactobacillus acidophilus La-14Altered Gut MicrobiotaBeneficial
Moderate
Lactobacillus acidophilus La-14Enhanced ImmunityBeneficial
Large
Lactobacillus acidophilus La-14Improved Immune ResponseBeneficial
Large
Lactobacillus acidophilus La-14Improved Intestinal Mucosal RepairBeneficial
Large
Lactobacillus acidophilus LA-5Improved Gut Microbiome CompositionBeneficial
Large
Lactobacillus acidophilus LA-5Improved Immune ResponseBeneficial
Large
Lactobacillus acidophilus LA-5Improved Intestinal Mucosal RepairBeneficial
Large
Lactobacillus acidophilus LA85Improved Gut Microbiome CompositionBeneficial
Large
Lactobacillus acidophilus LA85Improved Immune ResponseBeneficial
Large
Lactobacillus acidophilus LA85Improved Intestinal Mucosal RepairBeneficial
Large
Lactobacillus acidophilus MAK32L61AImproved Gut Microbiota CompositionBeneficial
Large
Lactobacillus acidophilus MAK32L61AImproved Immune ResponseBeneficial
Large
Lactobacillus acidophilus MAK32L61AImproved Intestinal Mucosal RepairBeneficial
Large
Lactobacillus acidophilus R0418Altered Gut MicrobiotaBeneficial
Moderate
Lactobacillus acidophilus R0418Improved Immune ResponseBeneficial
Large
Lactobacillus acidophilus R0418Improved Intestinal Mucosal RepairBeneficial
Large

Pillser helps you make informed health decisions by providing comprehensive, unbiased information about supplements. This includes detailed research on supplement ingredients, their benefits, potential risks, and their overall efficacy. You can contribute by sharing your feedback and suggestions.

Send us an email at support@pillser.com.