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Lactobacillus Acidophilus strain L-92 regulates the production of Th1 cytokine as well as Th2 cytokines.

  • 2007
  • Allergology International 56(3)
    • Akiko Torii
    • S. Torii
    • S. Fujiwara
    • Hiroyuki Tanaka
    • N. Inagaki
    • H. Nagai


Background: There is growing interest in probiotics such as lactic acid bacteria (LAB), not only for treatment of T helper type (Th) 1-mediated diseases but also for Th2-mediated diseases, including allergic diseases, since lactic acid bacteria may be able to modulate the Th1/Th2 balance, in addition to having an immunomodulative effect through induction of Th1 bias.

Methods: The effect of oral administration of heat-killed Lactobacillus acidophilus Strain L-92 (L-92) on ovalbumin (OVA)-specific immunoglobulin (Ig)E production was investigated in BALB/c mice. L-92 was orally administered to mice for 8 weeks from 2 weeks after initiation of OVA-immunization. Patterns of cytokine and Ig production in splenocytes and cells from Peyer's patches (PPs) from these mice were examined after restimulation with OVA in vitro.

Results: L-92 significantly suppressed serum OVA-specific IgE levels for a long period. Cytokines such as interferon (IFN)-gamma, interleukin (IL)-4 and IL-10 and Igs such as total IgE and OVA-specific IgE were produced at significantly lower levels by splenocytes of L-92-treated mice, compared with those of control mice. In contrast, transforming growth factor (TGF)-beta and IgA levels produced by PPs from L-92-treated mice were significantly higher than in those from control mice.

Conclusions: Oral L-92 administration regulated both Th1 and Th2 cytokine responses, suppressed serum OVA-specific IgE, and induced TGF-beta production in PPs. TGF-beta is known to be associated with activation of regulatory T (Treg) cells. These data suggest that LAB may have immunomodulative effect by Treg cells via TGF-beta activity.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus acidophilus L-92Increased IgA Production by PPsBeneficial
Lactobacillus acidophilus L-92Increased TGF-Beta Production by Plasma ProteinsBeneficial
Lactobacillus acidophilus L-92Reduced Serum OVA-specific IgE LevelsBeneficial

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