Skip to main content

Abstract

The aim of this study was to examine the effects of Lactobacillus brevis on the microbial community and serum metabolome in colitis induced by dextran sulfate sodium (DSS). ICR mice were randomly distributed into three treatment groups: (i) L. brevis treatment alone (control), (ii) DSS administration alone, and (iii) treatment with L. brevis and DSS. Our results demonstrate that L. brevis treatment significantly alleviated DSS-induced body weight loss and colon inflammation. In addition, LC-MS analysis of serum metabolites revealed that L. brevis treatment increased the serum level of metabolites against inflammatory responses or oxidative stressors caused by DSS in the murine model. By detecting colonic microbiota, L. brevis increased colonic microbial diversity after challenging with DSS, and increased the relative abundance of Alloprevotella at genus, but Bacteroidales was reduced (P < 0.05). These result indicated that L. brevis could lower the severity of colitis induced by DSS via improving reprogramming the serum metabolome and intestinal microbiota. These findings suggest that the probiotic L. brevis may prevent tissue damage from colitis.

Keywords: Lactobacillus brevis; colitis; intestinal microbiota; metabolome; murine.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus brevisImproved Gut Microbiota DiversityBeneficial
Moderate
Lactobacillus brevis HA-112Improved Colonic Microbial DiversityBeneficial
Moderate
Lactobacillus brevis HA-112Increased Serum Metabolites to Combat InflammationBeneficial
Moderate
Lactobacillus brevis HA-112Reduced Colitis SymptomsBeneficial
Large
Lactobacillus brevis HA-112Reduced Relative Abundance of BacteroidalesNeutral
Small
Lactobacillus brevis LB01Improved Gut Microbiota DiversityBeneficial
Moderate
Lactobacillus brevis LB01Increased Alloprevotella AbundanceBeneficial
Small
Lactobacillus brevis LB01Increased Serum Anti-inflammatory MetabolitesBeneficial
Moderate
Lactobacillus brevis LB01Reduced Relative Abundance of BacteroidalesNeutral
Small
Lactobacillus brevis Lbr-35Enhanced Serum Metabolite Levels Against InflammationBeneficial
Moderate
Lactobacillus brevis Lbr-35Improved Gut Microbiota DiversityBeneficial
Moderate
Lactobacillus brevis Lbr-35Increased Alloprevotella AbundanceBeneficial
Small
Lactobacillus brevis Lbr-35Reduced Body Weight LossBeneficial
Large
Lactobacillus brevis Lbr-35Reduced Colonic InflammationBeneficial
Large
Lactobacillus brevis Lbr-35Reduced Relative Abundance of BacteroidalesNeutral
Small
Lactobacillus brevis MAK11L82BElevated Serum Metabolites in Response to InflammationBeneficial
Moderate
Lactobacillus brevis MAK11L82BImproved Gut Microbiota DiversityBeneficial
Moderate
Lactobacillus brevis MAK11L82BIncreased Alloprevotella AbundanceBeneficial
Small
Lactobacillus brevis MAK11L82BReduced Colitis SymptomsBeneficial
Large
Lactobacillus brevis SBC8803Improved Gut Microbiota DiversityBeneficial
Moderate
Lactobacillus brevis SBC8803Increased Alloprevotella AbundanceBeneficial
Small
Lactobacillus brevis SBC8803Reduced Body WeightBeneficial
Large
Lactobacillus brevis SBC8803Reduced Colitis SeverityBeneficial
Large
Lactobacillus brevis SBC8803Reduced Colonic InflammationBeneficial
Large
Lactobacillus brevis SBC8803Reduced Relative Abundance of BacteroidalesNeutral
Small
Lactobacillus brevis SBC8803Reduced Tissue Damage from ColitisBeneficial
Large
Lactobacillus brevis SD5214Increased Serum Anti-inflammatory MetabolitesBeneficial
Moderate
Lactobacillus brevis SD-5214Improved Gut Microbiota DiversityBeneficial
Moderate
Lactobacillus brevis SD-5214Reduced Colitis SeverityBeneficial
Large
Lactobacillus brevis SD-5214Reduced Severity of DSS-Induced ColitisBeneficial
Large
Lactobacillus brevis UALbr-02Improved Gut Microbiota DiversityBeneficial
Moderate
Lactobacillus brevis UALbr-02Increased Alloprevotella AbundanceBeneficial
Small
Lactobacillus brevis UALbr-02Increased Anti-Inflammatory Marker LevelsBeneficial
Moderate
Lactobacillus brevis UALbr-02Reduced Body Weight LossBeneficial
Large
Lactobacillus brevis UALbr-02Reduced Colonic InflammationBeneficial
Large
Lactobacillus brevis UALbr-02Reduced Relative Abundance of BacteroidalesNeutral
Small
Lactobacillus brevis VPro 18Reduced DSS-Induced Body Weight LossBeneficial
Moderate

Pillser helps you make informed health decisions by providing comprehensive, unbiased information about supplements. This includes detailed research on supplement ingredients, their benefits, potential risks, and their overall efficacy. You can contribute by sharing your feedback and suggestions.

Send us an email at support@pillser.com.