Lactobacillus crispatus KBL693 alleviates atopic dermatitis symptoms through immune modulation.
- 2025-10-31
- Journal of microbiology (Seoul, Korea) 63(10)
- PubMed: 41164963
- DOI: 10.71150/jm.2509005
Study Design
- Methods
- In vitro, KBL693 suppressed mast cell degranulation and IL-4 production by T cells; in a murine AD model, oral administration of KBL693 was tested.
Atopic dermatitis (AD) is a widespread inflammatory skin condition that affects the population worldwide. Given the implication of microbiota in AD pathogenesis, we investigated whether human-derived Lactobacillus strains could modulate AD. In this study, we identified Lactobacillus crispatus KBL693 as a probiotic candidate for AD treatment. In vitro, KBL693 suppressed mast cell degranulation and IL-4 production by T cells, suggesting its ability to attenuate key type 2 immune responses. Consistent outcomes were observed in a murine AD model, where oral administration of KBL693 alleviated disease symptoms and reduced hallmark type 2 immune markers, including plasma IgE as well as IL-4, IL-5, and IL-13 levels in skin lesions. In addition to downregulating these AD-associated immune responses, KBL693 promoted regulatory T cell (Treg) expansion in mesenteric lymph nodes, indicating its potential to restore immune balance. Collectively, these findings highlight the therapeutic potential of KBL693 for AD through enhancement of Tregs and suppression of type 2 immune responses.
Research Insights
| Supplement | Dose | Health Outcome | Effect Type | Effect Size | Source |
|---|---|---|---|---|---|
| Lactobacillus crispatus | — | Improved Atopic Dermatitis Symptoms | Beneficial | Moderate | View sourceoral administration of KBL693 alleviated disease symptoms and reduced hallmark type 2 immune markers, including plasma IgE as well as IL-4, IL-5, and IL-13 levels in skin lesions |
| Lactobacillus crispatus | — | Increased Regulatory T Cell Expansion | Beneficial | Small | View sourceKBL693 promoted regulatory T cell (Treg) expansion in mesenteric lymph nodes |
| Lactobacillus crispatus | — | Reduced Type 2 Immune Responses | Beneficial | Moderate | View sourceKBL693 suppressed mast cell degranulation and IL-4 production by T cells, suggesting its ability to attenuate key type 2 immune responses |