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Abstract

The effects of Lactobacillus gasseri JCM 1131(T) on isoflavonoid levels within the caecum and plasma were assessed in adult mice. Male 5-week-old mice were fed an AIN 93M diet for 30 d. Two groups of mice were administered either L. gasseri JCM 1131(T) (the LGI group) or physiological saline solution (the control (CI) group) daily for 5 d before dissection. The plasma daidzein concentration was significantly higher in the LGI group, however, their plasma equol concentration was significantly less than in the CI group. The total amount of equol present as aglycone in the caecum was significantly greater in the CI group, but there was no significant difference in the total daidzein present as caecal aglycone. In an in vitro incubation of daidzein with the faecal flora of mice, the equol concentration was significantly higher in the CI group. The numbers of lactobacilli present were significantly higher in the LGI group. The present data suggest that the administration of L. gasseri is likely to influence the effect of isoflavonoids on the host via changes in the gastrointestinal environment.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus gasseri LG-36Increased Caecal Equol ConcentrationNeutral
Moderate
Lactobacillus gasseri LG-36Increased Lactobacilli LevelsBeneficial
Large
Lactobacillus gasseri LG-36Increased Plasma Daidzein LevelsBeneficial
Moderate
Lactobacillus gasseri LG-36Reduced Plasma Equol ConcentrationNeutral
Small
Lactobacillus gasseri LQ-36Increased Caecal Equol Aglycone LevelsHarmful
Large
Lactobacillus gasseri LQ-36Increased Lactobacilli LevelsBeneficial
Large
Lactobacillus gasseri LQ-36Increased Plasma Daidzein LevelsBeneficial
Moderate
Lactobacillus gasseri LQ-36Reduced Plasma Equol ConcentrationNeutral
Small
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