Lactobacillus johnsonii CJLJ103 Attenuates Scopolamine-Induced Memory Impairment in Mice by Increasing BDNF Expression and Inhibiting NF-κB Activation.
- 2018-09-28
- Journal of Microbiology and Biotechnology 28(9)
- Hae-Ji Lee
- Su-Min Lim
- Dong-Hyun Kim
- PubMed: 30111074
- DOI: 10.4014/jmb.1805.05025
Abstract
In the present study, we examined whether Lactobacillus johnsonii CJLJ103 (LJ) could alleviate cholinergic memory impairment in mice. Oral administration of LJ alleviated scopolamine-induced memory impairment in passive avoidance and Y-maze tasks. Furthermore, LJ treatment increased scopolamine-suppressed BDNF expression and CREB phosphorylation in the hippocampi of the brain, as well as suppressed TNF-α expression and NF-κB activation. LJ also increased BDNF expression in corticosterone-stimulated SH-SY5Y cells and inhibited NF-κB activation in LPS-stimulated microglial BV2 cells. However, LJ did not inhibit acetylcholinesterase activity. These findings suggest that LJ, a member of human gut microbiota, may mitigate cholinergic memory impairment by increasing BDNF expression and inhibiting NF-κB activation.
Keywords: BDNF; Lactobacillus johnsonii; NF-κB; memory impairment.
Research Insights
Supplement | Health Outcome | Effect Type | Effect Size |
---|---|---|---|
Lactobacillus johnsonii LJ09 | Enhanced Brain-Derived Neurotrophic Factor Levels | Beneficial | Moderate |
Lactobacillus johnsonii LJ09 | Improved Memory Function | Beneficial | Moderate |
Lactobacillus johnsonii LJ09 | Inhibited NF-κB Activation | Beneficial | Moderate |
Lactobacillus johnsonii LJ09 | Suppressed TNF-α Expression | Beneficial | Moderate |