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In the present study, we examined whether Lactobacillus johnsonii CJLJ103 (LJ) could alleviate cholinergic memory impairment in mice. Oral administration of LJ alleviated scopolamine-induced memory impairment in passive avoidance and Y-maze tasks. Furthermore, LJ treatment increased scopolamine-suppressed BDNF expression and CREB phosphorylation in the hippocampi of the brain, as well as suppressed TNF-α expression and NF-κB activation. LJ also increased BDNF expression in corticosterone-stimulated SH-SY5Y cells and inhibited NF-κB activation in LPS-stimulated microglial BV2 cells. However, LJ did not inhibit acetylcholinesterase activity. These findings suggest that LJ, a member of human gut microbiota, may mitigate cholinergic memory impairment by increasing BDNF expression and inhibiting NF-κB activation.

Keywords: BDNF; Lactobacillus johnsonii; NF-κB; memory impairment.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus johnsonii LJ09Enhanced Brain-Derived Neurotrophic Factor LevelsBeneficial
Lactobacillus johnsonii LJ09Improved Memory FunctionBeneficial
Lactobacillus johnsonii LJ09Inhibited NF-κB ActivationBeneficial
Lactobacillus johnsonii LJ09Suppressed TNF-α ExpressionBeneficial
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