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Lactobacillus paracasei modulates the gut microbiota and improves inflammation in type 2 diabetic rats.

  • 2021
  • Food & Function 12(15)
    • Zhu Zeng
    • Xiaoxuan Guo
    • Jinlan Zhang
    • Qipeng Yuan
    • Shangwu Chen

Abstract

This study aimed to investigate the effects of probiotic Lactobacillus paracasei NL41 on inflammation and the gut microbiota of type 2 diabetic (T2D) rats induced by high-fat diet (HFD) and low-dose streptozotocin (STZ). A T2D rat model was established by inducing Sprague-Dawley rats with HFD/STZ, followed by 12-weeks L. paracasei NL41 gavage. The blood, colonic tissues, and feces samples of these rats were collected for inflammation, histology, and intestinal microbiota profiling. L. paracasei NL41 treatment induced remarkable improvement in the inflammatory status by decreasing the levels of serum lipopolysaccharides (LPS), free fatty acids (FFA), tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-8 and increasing the level of IL-10. Gut barrier function was significantly protected in NL41-treated rats. Moreover, the strain NL41 induced changes in the microbiota structure and influenced the relative abundance of the key species. Specifically, Bacteroides, Clostridia (specifically, Ruminococcus torques), and Parasutterella were significantly reduced, while some beneficial microorganisms (Bacteroidales_S24-7_group and the families Lachnospiraceae and Ruminococcaceae) were enriched by NL41. The correlational analyses indicated that L. paracasei NL41 ameliorating inflammation was closely related to the key species of the gut microbiota. The present study indicates that probiotic L. paracasei NL41 decreases LPS-induced inflammation by improving the gut microbiota and preserving intestinal integrity.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lacticaseibacillus paracasei Lpc-37Altered Gut MicrobiotaBeneficial
Large
Lacticaseibacillus paracasei Lpc-37Improved Intestinal Barrier FunctionBeneficial
Large
Lacticaseibacillus paracasei Lpc-37Reduced InflammationBeneficial
Large
Lactobacillus paracaseiImproved Gut Barrier FunctionBeneficial
Moderate
Lactobacillus paracaseiImproved Gut Microbiome CompositionBeneficial
Large
Lactobacillus paracaseiReduced Inflammatory ResponseBeneficial
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Lactobacillus paracasei 431Altered Gut Microbiota CompositionBeneficial
Large
Lactobacillus paracasei 431Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus paracasei 431Increased Beneficial Gut MicrobiotaBeneficial
Moderate
Lactobacillus paracasei 431Reduced InflammationBeneficial
Large
Lactobacillus paracasei DSM 13434Altered Gut MicrobiotaBeneficial
Large
Lactobacillus paracasei DSM 13434Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus paracasei DSM 13434Reduced Inflammation LevelsBeneficial
Large
Lactobacillus paracasei HA-196Altered Gut MicrobiotaBeneficial
Large
Lactobacillus paracasei HA-196Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus paracasei HA-196Reduced Inflammation LevelsBeneficial
Large
Lactobacillus paracasei IMC 502Altered Gut Microbiota CompositionBeneficial
Large
Lactobacillus paracasei IMC 502Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus paracasei IMC 502Reduced Inflammation LevelsBeneficial
Large
Lactobacillus paracasei LPC09Altered Gut Microbiota CompositionBeneficial
Large
Lactobacillus paracasei LPC09Improved Inflammatory StatusBeneficial
Large
Lactobacillus paracasei LPC09Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus paracasei MCC1849Improved Gut Microbiome CompositionBeneficial
Large
Lactobacillus paracasei MCC1849Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus paracasei MCC1849Reduced Inflammation LevelsBeneficial
Large
Lactobacillus paracasei subsp. paracasei UALpc-04Enhanced Intestinal IntegrityBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALpc-04Improved Microbiota CompositionBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALpc-04Reduced InflammationBeneficial
Large
Lactobacillus paracasei subsp. paracasei UALs-04Reduced InflammationBeneficial
Large
Lactobacillus paracasei UALpc-04Improved Gut Microbiota CompositionBeneficial
Large
Lactobacillus paracasei UALpc-04Improved Inflammatory StatusBeneficial
Large
Lactobacillus paracasei UALpc-04Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus paracasei UALpc-04Reduced Plasma Lipopolysaccharide LevelsBeneficial
Moderate
Lactobacillus paracasei VPro 224Altered Gut Microbiota CompositionBeneficial
Large
Lactobacillus paracasei VPro 224Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus paracasei VPro 224Reduced Inflammation LevelsBeneficial
Large
Lactobacillus paracasei VPro 224Reduced Inflammation via Gut MicrobiotaBeneficial
Large
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