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Lactobacillus paracasei ssp. paracasei YBJ01 reduced d-galactose-induced oxidation in male Kuming mice.

  • 2018-12
  • Journal of Dairy Science 101(12)
    • Huayi Suo
    • Shanchun Liu
    • Jian Li
    • Yangping Ding
    • Hongwei Wang
    • Yu Zhang
    • Xin Zhao
    • Jia-Le Song


We investigated in vitro and in vivo antioxidant activity of Lactobacillus paracasei ssp. paracasei YBJ01 (LPSP-YBJ01) isolated and identified from fermented yogurt. Strain LPSP-YBJ01 had stress tolerance against acidity, bile salt, and osmotic pressure. Five in vitro antioxidant assays were used to evaluate antioxidant activity of LPSP-YBJ01, which could scavenge free radicals (2,2-diphenyl-1-picrylhydrazyl and hydroxyl) and superoxide anion in vitro. In addition, strain LPSP-YBJ01 had stronger antilipid peroxidation activity and weak reducing power in vitro. We measured in vivo antioxidant activity of LPSP-YBJ01 in an oxidation mouse model induced by d-galactose injection. Strain LPSP-YBJ01 significantly increased serum superoxide dismutase (SOD), glutathione peroxidase, and total-antioxidant capability, and inhibited generation of malondialdehyde in a dose-dependent manner. In addition, strain LPSP-YBJ01 also increased the hepatic and splenic protein expressions of some antioxidant enzymes such as catalase, Cu/Zn-SOD, and Mn-SOD in mice treated with d-galactose. Thus, LPSP-YBJ01 had antioxidant activity in vitro and in vivo and may be a useful probiotic.

Keywords: Lactobacillus paracasei ssp. paracasei YBJ01; d-galactose; in vitro antioxidant; oxidation mice.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus paracasei LPC09Increased Antioxidant CapacityBeneficial
Lactobacillus paracasei LPC09Increased Glutathione Peroxidase LevelsBeneficial
Lactobacillus paracasei LPC09Increased Serum Superoxide Dismutase LevelsBeneficial
Lactobacillus paracasei LPC09Reduced Malondialdehyde GenerationBeneficial
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