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Abstract

Scope: The study aims to determine whether Lactobacillus plantarum C29-fermented defatted soybean (FDS, DW2009) can attenuate memory impairment in 5XFAD transgenic (Tg) mice.

Methods and results: Oral administration of FDS or C29 increases cognitive function in Tg mice in passive avoidance, Y-maze, novel object recognition, and Morris water maze tasks. FDS or C29 treatment significantly suppresses amyloid-β, β/γ-secretases, caspase-3 expression, and NF-κB activation, and activates microglia and apoptotic neuron cell populations, and increases BDNF expression in the brain. FDS or C29 treatment suppresses blood and fecal lipopolysaccharide levels and Enterobacteriaceae population and increases lactobacilli/bifidobacteria populations.

Conclusion: FDS and C29 alleviates the decrease in cognitive function and inhibited amyloid-β expression in Tg mice by regulating microglia activation and gut microbiota composition.

Keywords: amyloid-β; fermented defatted soybean; lactobacillus plantarum; memory impairment; microglia.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus plantarum SD-5209Improved Cognitive FunctionBeneficial
Large
Lactobacillus plantarum SD-5209Improved Gut Microbiome CompositionBeneficial
Moderate
Lactobacillus plantarum SD-5209Increased Serum BDNF LevelsBeneficial
Moderate
Lactobacillus plantarum SD-5209Reduced Amyloid-β LevelsBeneficial
Large
Lactobacillus plantarum SD-5209Regulated Microglial ActivationBeneficial
Moderate
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