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Abstract

Here, the aim was to evaluate the protective effect of Lactobacillus plantarum-derived postbiotics, i.e., LP-cs, on acute alcoholic liver injury (ALI). After preincubation with LP-cs, HL7702 human hepatocytes were treated with alcohol, and then the cell survival rate was measured. C57BL/6 male mice were presupplemented with or without LP-cs and LP-cs-loaded calcium alginate hydrogel (LP-cs-Gel) for 3 weeks and given 50% alcohol gavage to establish the mouse model of ALI, LP-cs presupplementation, and LP-cs-Gel presupplementation. The histomorphology of the liver and intestines; the levels of serum AST, ALT, lipid, and SOD activity; liver transcriptomics; and the metagenome of intestinal microbiota were detected in all mouse models. In vitro, LP-cs significantly increased the survival rate of alcohol-treated cells. In vivo, presupplementation with LP-cs and LP-cs-Gel restored the levels of serum AST, ALT, and SOD activity, as well as TC and TG, after acute alcohol intake. In the LP-cs-presupplemented mice, the genes involved in fatty acid metabolic processes were upregulated and the genes involved in steroid biosynthesis were downregulated significantly as compared with the ALI mice. LP-cs significantly increased the abundance of intestinal microbiota, especially Akkermansia muciniphila. In conclusion, LP-cs ameliorates ALI by protecting hepatocytes against oxidative damage, thereby, improving lipid metabolism and regulating the intestinal microbiota. The effect of LP-cs-Gel is similar to that of LP-cs.

Keywords: Lactobacillus plantarum; alcoholic liver injury; intestinal microbiota; postbiotic.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactiplantibacillus plantarum Lp-115Improved Cell Survival RatesBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Improved Lipid MetabolismBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Improved Serum AveragesBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Increased Gut Microbiota AbundanceBeneficial
Large
Lactobacillus plantarum 14DEnhanced Fatty Acid MetabolismBeneficial
Moderate
Lactobacillus plantarum 14DImproved Cell Survival RatesBeneficial
Moderate
Lactobacillus plantarum 14DImproved Gut MicrobiotaBeneficial
Large
Lactobacillus plantarum 14DImproved Liver FunctionBeneficial
Moderate
Lactobacillus plantarum DR7Improved Lipid MetabolismBeneficial
Moderate
Lactobacillus plantarum DR7Increased Gut Microbiota AbundanceBeneficial
Large
Lactobacillus plantarum DR7Increased Survival Rate of Alcohol-Treated CellsBeneficial
Large
Lactobacillus plantarum DR7Reduced Oxidative DamageBeneficial
Large
Lactobacillus plantarum DR7Restored SOD Activity LevelsBeneficial
Large
Lactobacillus plantarum LP-01Enhanced Fatty Acid MetabolismBeneficial
Moderate
Lactobacillus plantarum LP-01Improved Serum SOD ActivityBeneficial
Moderate
Lactobacillus plantarum LP-01Increased Abundance of Akkermansia MuciniphilaBeneficial
Moderate
Lactobacillus plantarum LP-01Increased Survival Rate of Alcohol-Treated CellsBeneficial
Large
Lactobacillus plantarum LP09Improved Cell Survival RatesBeneficial
Moderate
Lactobacillus plantarum LP09Improved Lipid MetabolismBeneficial
Moderate
Lactobacillus plantarum LP09Increased Gut Microbiota AbundanceBeneficial
Large
Lactobacillus plantarum Lp-115Improved Intestinal Microbiota HealthBeneficial
Moderate
Lactobacillus plantarum Lp-115Improved Lipid MetabolismBeneficial
Moderate
Lactobacillus plantarum Rosell-AImproved Cell Survival RatesBeneficial
Moderate
Lactobacillus plantarum Rosell-AImproved Gut Microbiota DiversityBeneficial
Large
Lactobacillus plantarum Rosell-AImproved Lipid MetabolismBeneficial
Moderate
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