Lactobacillus plantarum DP189 Reduces α-SYN Aggravation in MPTP-Induced Parkinson's Disease Mice via Regulating Oxidative Damage, Inflammation, and Gut Microbiota Disorder.
- 2022-01-24
- Journal of Agricultural and Food Chemistry 70(4)
- Lei Wang
- Zijian Zhao
- Lei Zhao
- Yujuan Zhao
- Ge Yang
- Chao Wang
- Lei Gao
- Chunhua Niu
- Shengyu Li
- PubMed: 35067061
- DOI: 10.1021/acs.jafc.1c07711
Abstract
This study aimed to evaluate the attenuating effect of Lactobacillus plantarum DP189 on α-synuclein (α-SYN) aggregates in the substantia nigra (SN) of Parkinson's disease (PD) mice via 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced. Our results indicated that L. plantarum DP189 increased the levels of superoxide dismutase (SOD), glutathione peroxide (GSH-Px), and interleukin-10 (IL-10) and decreased the levels of malondialdehyde (MDA), reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β). Moreover, L. plantarum DP189 reduced the α-SYN accumulation in SN. Mechanistically, L. plantarum DP189 activated the expression of nuclear factor erythroid 2-related factor (Nrf2)/ARE and PGC-1α pathways and suppressed the NLRP3 inflammasome. Furthermore, fecal analysis showed that L. plantarum DP189 reshaped the gut microbiota in PD mice by reducing the number of pathogenic bacteria (Proteobacteria and Actinobacteria) and increased the abundance of probiotics (Lactobacillus and Prevotella). Our results suggested that L. plantarum DP189 could delay the neurodegeneration caused by the accumulation of α-SYN in the SN of PD mice via suppressing oxidative stress, repressing proinflammatory response, and modulating gut microbiota.
Keywords: Lactobacillus plantarum; Parkinson’s disease; antioxidant; gut−brain axis; neuroinflammation; probiotic.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus plantarum 14D | Modulated Gut Microbiota | Beneficial | Moderate |
| Lactobacillus plantarum 14D | Reduced Alpha-Synuclein Accumulation | Beneficial | Moderate |
| Lactobacillus plantarum 14D | Reduced Inflammation | Beneficial | Moderate |
| Lactobacillus plantarum 14D | Reduced Oxidative Stress | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6595 | Reduced Alpha-Synuclein Accumulation | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6595 | Reduced Dysbiosis | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6595 | Reduced Hepatic Oxidative Stress | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6595 | Reduced Inflammation Levels | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6596 | Altered Gut Microbiota | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6596 | Reduced Alpha-Synuclein Accumulation | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6596 | Reduced Hepatic Oxidative Stress | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6596 | Reduced Inflammation Levels | Beneficial | Moderate |
| Lactobacillus plantarum KABP™-061 | Improved Gut Microbiome Composition | Beneficial | Moderate |
| Lactobacillus plantarum KABP™-061 | Reduced Alpha-Synuclein Accumulation | Beneficial | Moderate |
| Lactobacillus plantarum KABP™-061 | Reduced Hepatic Oxidative Stress | Beneficial | Moderate |
| Lactobacillus plantarum KABP™-061 | Reduced Inflammation Levels | Beneficial | Moderate |
| Lactobacillus plantarum LP09 | Elevated Antioxidant Levels | Beneficial | Moderate |
| Lactobacillus plantarum LP09 | Enhanced Antioxidant Activity | Beneficial | Moderate |
| Lactobacillus plantarum LP09 | Improved Gut Microbiome Composition | Beneficial | Moderate |
| Lactobacillus plantarum LP09 | Reduced Alpha-Synuclein Accumulation | Beneficial | Moderate |
| Lactobacillus plantarum LP09 | Reduced Neuroinflammation | Beneficial | Moderate |
| Lactobacillus plantarum LP09 | Reduced Oxidative Damage | Beneficial | Large |
| Lactobacillus plantarum LP09 | Suppressed NLRP3 Inflammasome Activity | Beneficial | Moderate |
| Lactobacillus plantarum SD-5209 | Altered Gut Microbiota | Beneficial | Moderate |
| Lactobacillus plantarum SD-5209 | Elevated Antioxidant Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD-5209 | Increased Anti-Inflammatory Cytokine Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD-5209 | Reduced Hepatic Oxidative Stress | Beneficial | Moderate |
| Lactobacillus plantarum SD-5209 | Reduced Inflammatory Response | Beneficial | Moderate |
| Lactobacillus plantarum SD-5209 | Reduced α-Synuclein Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD5209 | Delayed Neurodegeneration | Beneficial | Moderate |
| Lactobacillus plantarum SD5209 | Reduced Alpha-Synuclein Accumulation | Beneficial | Moderate |
| Lactobacillus plantarum SD5209 | Reduced Hepatic Oxidative Stress | Beneficial | Moderate |
| Lactobacillus plantarum SD5209 | Reduced Inflammation Levels | Beneficial | Moderate |
| Lactobacillus plantarum VPro 10 | Elevated Antioxidant Levels | Beneficial | Moderate |
| Lactobacillus plantarum VPro 10 | Improved Gut Microbiome Composition | Beneficial | Moderate |
| Lactobacillus plantarum VPro 10 | Reduced Inflammatory Response | Beneficial | Moderate |
| Lactobacillus plantarum VPro 10 | Reduced α-Synuclein Levels | Beneficial | Moderate |