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Lactobacillus plantarum DP189 Reduces α-SYN Aggravation in MPTP-Induced Parkinson's Disease Mice via Regulating Oxidative Damage, Inflammation, and Gut Microbiota Disorder.

  • 2022-01-24
  • Journal of Agricultural and Food Chemistry 70(4)
    • Lei Wang
    • Zijian Zhao
    • Lei Zhao
    • Yujuan Zhao
    • Ge Yang
    • Chao Wang
    • Lei Gao
    • Chunhua Niu
    • Shengyu Li

Abstract

This study aimed to evaluate the attenuating effect of Lactobacillus plantarum DP189 on α-synuclein (α-SYN) aggregates in the substantia nigra (SN) of Parkinson's disease (PD) mice via 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced. Our results indicated that L. plantarum DP189 increased the levels of superoxide dismutase (SOD), glutathione peroxide (GSH-Px), and interleukin-10 (IL-10) and decreased the levels of malondialdehyde (MDA), reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β). Moreover, L. plantarum DP189 reduced the α-SYN accumulation in SN. Mechanistically, L. plantarum DP189 activated the expression of nuclear factor erythroid 2-related factor (Nrf2)/ARE and PGC-1α pathways and suppressed the NLRP3 inflammasome. Furthermore, fecal analysis showed that L. plantarum DP189 reshaped the gut microbiota in PD mice by reducing the number of pathogenic bacteria (Proteobacteria and Actinobacteria) and increased the abundance of probiotics (Lactobacillus and Prevotella). Our results suggested that L. plantarum DP189 could delay the neurodegeneration caused by the accumulation of α-SYN in the SN of PD mice via suppressing oxidative stress, repressing proinflammatory response, and modulating gut microbiota.

Keywords: Lactobacillus plantarum; Parkinson’s disease; antioxidant; gut−brain axis; neuroinflammation; probiotic.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus plantarum 14DModulated Gut MicrobiotaBeneficial
Moderate
Lactobacillus plantarum 14DReduced Alpha-Synuclein AccumulationBeneficial
Moderate
Lactobacillus plantarum 14DReduced InflammationBeneficial
Moderate
Lactobacillus plantarum 14DReduced Oxidative StressBeneficial
Moderate
Lactobacillus plantarum DSM 6595Reduced Alpha-Synuclein AccumulationBeneficial
Moderate
Lactobacillus plantarum DSM 6595Reduced DysbiosisBeneficial
Moderate
Lactobacillus plantarum DSM 6595Reduced Hepatic Oxidative StressBeneficial
Moderate
Lactobacillus plantarum DSM 6595Reduced Inflammation LevelsBeneficial
Moderate
Lactobacillus plantarum DSM 6596Altered Gut MicrobiotaBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced Alpha-Synuclein AccumulationBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced Hepatic Oxidative StressBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced Inflammation LevelsBeneficial
Moderate
Lactobacillus plantarum KABP™-061Improved Gut Microbiome CompositionBeneficial
Moderate
Lactobacillus plantarum KABP™-061Reduced Alpha-Synuclein AccumulationBeneficial
Moderate
Lactobacillus plantarum KABP™-061Reduced Hepatic Oxidative StressBeneficial
Moderate
Lactobacillus plantarum KABP™-061Reduced Inflammation LevelsBeneficial
Moderate
Lactobacillus plantarum LP09Elevated Antioxidant LevelsBeneficial
Moderate
Lactobacillus plantarum LP09Enhanced Antioxidant ActivityBeneficial
Moderate
Lactobacillus plantarum LP09Improved Gut Microbiome CompositionBeneficial
Moderate
Lactobacillus plantarum LP09Reduced Alpha-Synuclein AccumulationBeneficial
Moderate
Lactobacillus plantarum LP09Reduced NeuroinflammationBeneficial
Moderate
Lactobacillus plantarum LP09Reduced Oxidative DamageBeneficial
Large
Lactobacillus plantarum LP09Suppressed NLRP3 Inflammasome ActivityBeneficial
Moderate
Lactobacillus plantarum SD-5209Altered Gut MicrobiotaBeneficial
Moderate
Lactobacillus plantarum SD-5209Elevated Antioxidant LevelsBeneficial
Moderate
Lactobacillus plantarum SD-5209Increased Anti-Inflammatory Cytokine LevelsBeneficial
Moderate
Lactobacillus plantarum SD-5209Reduced Hepatic Oxidative StressBeneficial
Moderate
Lactobacillus plantarum SD-5209Reduced Inflammatory ResponseBeneficial
Moderate
Lactobacillus plantarum SD-5209Reduced α-Synuclein LevelsBeneficial
Moderate
Lactobacillus plantarum SD5209Delayed NeurodegenerationBeneficial
Moderate
Lactobacillus plantarum SD5209Reduced Alpha-Synuclein AccumulationBeneficial
Moderate
Lactobacillus plantarum SD5209Reduced Hepatic Oxidative StressBeneficial
Moderate
Lactobacillus plantarum SD5209Reduced Inflammation LevelsBeneficial
Moderate
Lactobacillus plantarum VPro 10Elevated Antioxidant LevelsBeneficial
Moderate
Lactobacillus plantarum VPro 10Improved Gut Microbiome CompositionBeneficial
Moderate
Lactobacillus plantarum VPro 10Reduced Inflammatory ResponseBeneficial
Moderate
Lactobacillus plantarum VPro 10Reduced α-Synuclein LevelsBeneficial
Moderate
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