Skip to main content

Lactobacillus plantarum L‐137 upregulates hyaluronic acid production in epidermal cells and fibroblasts in mice

  • 2019-07-29
  • Microbiology and Immunology 63(9)
    • Hiroko Nakai
    • Y. Hirose
    • S. Murosaki
    • Y. Yoshikai


Heat-killed Lactobacillus plantarum L-137 (HK L-137), an immunobiotic lactic acid bacterium, has been reported to enhance IFN-γ production through induction of IL-12. In this study, we investigated the effects of HK L-137 on skin moisturizing and production of hyaluronic acid (HA), an extracellular matrix associated with the retention of skin moisture. Oral administration of HK L-137 suppressed the loss of water content in the stratum corneum in hairless mice. Treatment of primary epidermal cells with HK L-137 increased HA production. Supernatant from immune cells stimulated by HK L-137, which contained proinflammatory cytokines such as IL-12, TNF-α, and IFN-γ, upregulated HA production and hyaluronan synthase 2 (HAS2) messenger RNA expression by BALB/3T3 fibroblasts via activation of transcription factor nuclear factor κB (NFκB). Although treatment of the supernatant with anti-TNF-α antibody (Ab) alone did not inhibit the HA production, combination of anti-TNF-α Ab with anti-IFN-γ Ab significantly inhibited the HA production. Thus, HK L-137-induced IFN-γ plays a critical role in upregulated HA production in collaboration with TNF-α. HK L-137 may be useful for improvement of skin functions such as moisture retention by inducing HA production.

Keywords: IFN-γ; Lactobacillus plantarum L-137; hyaluronic acid; skin.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus plantarum L-137Enhanced Interferon Gamma ProductionBeneficial
Lactobacillus plantarum L-137Improved Skin Moisture RetentionBeneficial
Lactobacillus plantarum L-137Increased Hyaluronic Acid ProductionBeneficial
⬆ Back to top
Supplement Research and Comparison Website: evidence-based information about supplements, their benefits, potential risks, and their efficacy.
Receive updates about our products, services, sales, and special offers. Unsubscribe anytime. See our Privacy Policy for details on how we handle your information.

Join Our Community

Use to get in touch.