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Abstract

Previous studies have suggested that the Lactobacillus plantarum bacteria strain could be effective in ulcerative colitis (UC) management. However, its effects are strain-specific and the related mechanisms for its attenuating effects on UC remain unclear. This study aimed to elucidate the underlying mechanisms for the protective effect of L. plantarum on UC. Firstly, 15 L. plantarum strains were screened for potential probiotic characteristics with good tolerance to simulated human gastrointestinal transit and adhesion. Secondly, the inflammatory response of selected strains to the Caco-2 cells induced by lipopolysaccharide (LPS) was measured. Finally, an in vivo mouse model induced by dextran sulfate sodium (DSS) was used to assess the beneficial effects and likely action mechanisms the successfully screened in vitro strain, L. plantarum L15. In vitro results showed that L. plantarum L15 possessed the highest gastrointestinal transit tolerance, adhesion and reduction of pro-inflammatory abilities compared to the other screened strains. In vivo, high dose of L. plantarum L15 supplementation increased the body weight, colon length and anti-inflammatory cytokine production. Pro-inflammatory cytokine production, disease activity index (DAI) levels and myeloperoxidase (MPO) parameters decreased using this strain. In addition, L. plantarum L15 alleviated the histopathological changes in colon, modulated the gut microbiota, and decreased LPS secretion. The activities of this strain down-regulated the expression of TLR4 and MyD88 genes as well as genes associated with NF-κB signaling pathway. Our findings present L. plantarum L15 as a new probiotic, with promising application for UC management.

Keywords: DSS-colitis; Lactobacillus plantarum; NF-κB signaling; gut microbiota; lipopolysaccharide (LPS).

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactiplantibacillus plantarum LP-1Alleviated Histopathological Changes in the ColonBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Altered Gut MicrobiotaBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Increased Anti-Inflammatory Cytokine LevelsBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Increased Body WeightBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Increased Colon LengthBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced Disease Activity Index (DAI) LevelsBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced LPS SecretionBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced Myeloperoxidase LevelsBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced Pro-Inflammatory CytokinesBeneficial
Moderate
Lactobacillus plantarum DSM 6596Alleviated Histopathological Changes in the ColonBeneficial
Moderate
Lactobacillus plantarum DSM 6596Altered Gut MicrobiotaBeneficial
Moderate
Lactobacillus plantarum DSM 6596Increased Anti-Inflammatory Cytokine LevelsBeneficial
Moderate
Lactobacillus plantarum DSM 6596Increased Body WeightBeneficial
Moderate
Lactobacillus plantarum DSM 6596Increased Colon LengthBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced Disease Activity Index (DAI) LevelsBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced LPS SecretionBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced Myeloperoxidase LevelsBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced Pro-Inflammatory CytokinesBeneficial
Moderate
Lactobacillus plantarum KABP™-061Alleviated Histopathological Changes in the ColonBeneficial
Moderate
Lactobacillus plantarum KABP™-061Altered Gut MicrobiotaBeneficial
Moderate
Lactobacillus plantarum KABP™-061Improved Body WeightBeneficial
Moderate
Lactobacillus plantarum KABP™-061Increased Anti-Inflammatory Cytokine LevelsBeneficial
Moderate
Lactobacillus plantarum KABP™-061Increased Colon LengthBeneficial
Moderate
Lactobacillus plantarum KABP™-061Reduced Disease Activity Index (DAI) LevelsBeneficial
Moderate
Lactobacillus plantarum KABP™-061Reduced LPS SecretionBeneficial
Moderate
Lactobacillus plantarum KABP™-061Reduced Myeloperoxidase LevelsBeneficial
Moderate
Lactobacillus plantarum KABP™-061Reduced Pro-Inflammatory CytokinesBeneficial
Moderate
Lactobacillus plantarum L-137Alleviated Histopathological Changes in the ColonBeneficial
Moderate
Lactobacillus plantarum L-137Altered Gut MicrobiotaBeneficial
Moderate
Lactobacillus plantarum L-137Increased Anti-Inflammatory Cytokine LevelsBeneficial
Moderate
Lactobacillus plantarum L-137Increased Body WeightBeneficial
Moderate
Lactobacillus plantarum L-137Increased Colon LengthBeneficial
Moderate
Lactobacillus plantarum L-137Reduced Disease Activity Index (DAI) LevelsBeneficial
Moderate
Lactobacillus plantarum L-137Reduced LPS SecretionBeneficial
Moderate
Lactobacillus plantarum L-137Reduced Myeloperoxidase LevelsBeneficial
Moderate
Lactobacillus plantarum L-137Reduced Pro-Inflammatory CytokinesBeneficial
Moderate
Lactobacillus plantarum LP-01Alleviated Histopathological Changes in the ColonBeneficial
Moderate
Lactobacillus plantarum LP-01Altered Gut MicrobiotaBeneficial
Moderate
Lactobacillus plantarum LP-01Increased Anti-Inflammatory Cytokine LevelsBeneficial
Moderate
Lactobacillus plantarum LP-01Increased Body WeightBeneficial
Moderate
Lactobacillus plantarum LP-01Increased Colon LengthBeneficial
Moderate
Lactobacillus plantarum LP-01Reduced Disease Activity Index (DAI) LevelsBeneficial
Moderate
Lactobacillus plantarum LP-01Reduced LPS SecretionBeneficial
Moderate
Lactobacillus plantarum LP-01Reduced Myeloperoxidase LevelsBeneficial
Moderate
Lactobacillus plantarum LP-01Reduced Pro-Inflammatory CytokinesBeneficial
Moderate
Lactobacillus plantarum Lp-115Alleviated Histopathological Changes in the ColonBeneficial
Moderate
Lactobacillus plantarum Lp-115Down-Regulated Genes in NF-κB Signaling PathwayBeneficial
Moderate
Lactobacillus plantarum Lp-115Increased Anti-Inflammatory Cytokine LevelsBeneficial
Moderate
Lactobacillus plantarum Lp-115Increased Body WeightBeneficial
Moderate
Lactobacillus plantarum Lp-115Increased Colon LengthBeneficial
Moderate
Lactobacillus plantarum Lp-115Modulated Gut MicrobiotaBeneficial
Large
Lactobacillus plantarum Lp-115Reduced Disease Activity Index (DAI) LevelsBeneficial
Moderate
Lactobacillus plantarum Lp-115Reduced LPS SecretionBeneficial
Moderate
Lactobacillus plantarum Lp-115Reduced Myeloperoxidase LevelsBeneficial
Moderate
Lactobacillus plantarum Lp-115Reduced Pro-Inflammatory CytokinesBeneficial
Moderate
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