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Lactobacillus plantarum NA136 ameliorates nonalcoholic fatty liver disease by modulating gut microbiota, improving intestinal barrier integrity, and attenuating inflammation

  • 2020-04-26
  • Applied Microbiology and Biotechnology 104(12)
    • Zijian Zhao
    • Long Chen
    • Yujuan Zhao
    • Chao Wang
    • Cui-cui Duan
    • Ge Yang
    • Chunhua Niu
    • Shengyu Li


Gut microbiota dysbiosis, associated with insulin resistance, weak intestinal barrier integrity, and inflammation, may also play a role in the development of dietary-induced nonalcoholic fatty liver disease (NAFLD). This study investigates the effects of dietary Lactobacillus plantarum NA136 administration on gut microbiota composition in an insulin-resistant C57BL/6J mouse NAFLD model. Comparison of mice with and without L. plantarum NA136 treatment revealed that L. plantarum NA136 treatment not only relieved insulin resistance but also significantly increased relative proportions of Desulfovibrio, Alistipes, Prevotella, and Enterorhabdus in gut microbiota of NAFLD mice. Meanwhile, L. plantarum NA136 administration also inhibited pathogenic bacterial growth, while promoting growth of probiotics such as Allobaculum, Lactobacillus, and, most markedly, Bifidobacterium. Moreover, L. plantarum NA136 treatment of NAFLD mice improved intestinal barrier integrity and attenuated high-fat and fructose diet (HFD/F)-induced inflammation. These results implicate gut-liver-axis-dependent microbiota modulation as the underlying mechanism for L. plantarum NA136-induced amelioration of NAFLD.Key points• L. plantarum NA136 corrects gut microbiota disorders caused by a high-fat and fructose diet. • L. plantarum NA136 strengthens the intestinal barrier and reduces inflammation in the liver. • L. plantarum NA136 relieves NAFLD by improving the gut-liver axis.

Keywords: Gut-liver axis; Inflammation; Intestinal barrier; Lactobacillus plantarum; NAFLD.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus plantarum DSM 6596Altered Gut MicrobiotaBeneficial
Lactobacillus plantarum DSM 6596Improved Insulin SensitivityBeneficial
Lactobacillus plantarum DSM 6596Improved Intestinal Barrier FunctionBeneficial
Lactobacillus plantarum DSM 6596Reduced Inflammation LevelsBeneficial
Lactobacillus plantarum DSM 6596Reduced Pathogenic BacteriaBeneficial
Lactobacillus plantarum N13Corrected Gut Microbiota DisordersBeneficial
Lactobacillus plantarum N13Enhanced Probiotic GrowthBeneficial
Lactobacillus plantarum N13Improved Insulin SensitivityBeneficial
Lactobacillus plantarum N13Improved Intestinal Barrier FunctionBeneficial
Lactobacillus plantarum N13Improved NAFLDBeneficial
Lactobacillus plantarum N13Reduced Inflammation LevelsBeneficial
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