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Abstract

Objective: To determine whether administration of Lactobacillus reuteri DSM 17938 is beneficial in functional abdominal pain (FAP) of childhood.

Study design: A total of 101 children, aged 6-15 years, who fulfilled the Rome III criteria for FAP were enrolled in a randomized double-blind, placebo-controlled trial, and were randomly assigned to receive either L reuteri DSM 17938 or placebo for 4 weeks, with further follow-up of additional 4 weeks. Response to therapy was based on a self-reported daily questionnaire monitoring frequency and intensity of abdominal pain, using the faces scoring system by Hicks.

Results: L reuteri (n = 47) was significantly superior to placebo (n = 46) in relieving frequency (1.9 ± 0.8 vs 3.6 ± 1.7 episodes/wk, P < .02) and intensity (4.3 ± 2.2 vs 7.2 ± 3.1 Hicks score/wk, P < .01) of abdominal pain following 4 weeks of supplementation. There was no difference in school absenteeism rate or other gastrointestinal symptoms, except for a lower incidence of perceived abdominal distention and bloating, favoring L reuteri.

Conclusions: L reuteri DSM 17938, compared with placebo, significantly reduced the frequency and intensity of FAP in children.

Trial registration: ClicalTrials.gov: NCT01180556.

Keywords: microbiota; probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus reuteriReduced Abdominal Pain FrequencyBeneficial
Large
Lactobacillus reuteriReduced Abdominal Pain IntensityBeneficial
Large
Lactobacillus reuteri DSM 17938Reduced Abdominal Pain FrequencyBeneficial
Large
Lactobacillus reuteri DSM 17938Reduced Abdominal Pain IntensityBeneficial
Large
Lactobacillus reuteri OsfortisReduced Abdominal Pain FrequencyBeneficial
Large
Lactobacillus reuteri OsfortisReduced Abdominal Pain IntensityBeneficial
Large
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