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Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function.

  • 2004-12
  • The American Journal of Clinical Nutrition 80(6)
    • H. Braat
    • Jan M. H. Van den Brande
    • E. V. van Tol
    • D. Hommes
    • M. Peppelenbosch
    • S. V. van Deventer

Abstract

Background: Although it is widely recognized that the intake of so-called probiotic microorganisms is beneficial in chronic mucosal inflammation and topical allergic disease, the immunologic details explaining how such bacteria can exert these effects remain obscure.

Objective: We determined whether Lactobacillus rhamnosus can modulate T cell responses in vitro and in vivo.

Design: In vitro, human monocyte-derived dendritic cells (DCs) matured in the presence of L. rhamnosus were used to instruct naive CD4+ T cells; subsequently, the T cell response was assessed with the use of CD3/CD28 and interleukin (IL) 2. Cytokine production by ex vivo-stimulated naive cells and memory T cells was measured before and after oral supplementation with L. rhamnosus in 6 healthy volunteers and 6 patients with Crohn disease.

Results: A decreased T cell proliferation and cytokine production, especially of IL-2, IL-4, and IL-10, was observed in CD3/CD28-stimulated T cells derived from L. rhamnosus-matured DCs. This T cell hyporesponsiveness was associated with enhanced DC-T cell interaction and normal responsiveness of T cells for IL-2. In vivo oral supplementation of L. rhamnosus for 2 wk induced a similar T cell hyporesponsiveness, including impaired ex vivo T helper subsets 1 and 2 responses without up-regulation of immunoregulatory cytokines in cohorts of both healthy volunteers and patients with Crohn disease.

Conclusions: We propose that L. rhamnosus modulates DC function to induce a novel form of T cell hyporesponsiveness; this mechanism might be an explanation for the observed beneficial effects of probiotic treatment in clinical disease.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lacticaseibacillus rhamnosusImpaired Ex Vivo T Helper Subset ResponsesBeneficial
Moderate
Lacticaseibacillus rhamnosusReduced T Cell ResponsivenessBeneficial
Moderate
Lactobacillus rhamnosusReduced T Cell ResponsivenessBeneficial
Moderate
Lactobacillus rhamnosus CLR1505Reduced T Cell ProliferationBeneficial
Moderate
Lactobacillus rhamnosus CRL 1505Enhanced Dendritic Cell-T Cell InteractionBeneficial
Moderate
Lactobacillus rhamnosus DSM 6594Reduced T Cell ProliferationBeneficial
Moderate
Lactobacillus rhamnosus HA-11Impaired Ex Vivo T Helper Subset ResponsesBeneficial
Moderate
Lactobacillus rhamnosus HA-11Reduced T Cell ProliferationBeneficial
Moderate
Lactobacillus rhamnosus HA-114Reduced T Cell ResponsivenessBeneficial
Moderate
Lactobacillus rhamnosus HA-500Reduced T Cell ResponsivenessBeneficial
Moderate
Lactobacillus rhamnosus IMC 501Reduced T Cell ProliferationBeneficial
Moderate
Lactobacillus rhamnosus LBV 96Reduced T Cell ProliferationBeneficial
Moderate
Lactobacillus rhamnosus LBV96Reduced T Cell ResponsivenessBeneficial
Moderate
Lactobacillus rhamnosus LCS-742Decreased Peripheral T Cell ResponseBeneficial
Moderate
Lactobacillus rhamnosus LR04Reduced Cytokine ProductionBeneficial
Moderate
Lactobacillus rhamnosus LR04Reduced T Cell ProliferationBeneficial
Moderate
Lactobacillus rhamnosus LR04Reduced T Cell ResponsivenessBeneficial
Moderate
Lactobacillus rhamnosus LR05Reduced T Cell ResponsivenessBeneficial
Moderate
Lactobacillus rhamnosus Lr-32Reduced T Cell ResponsivenessBeneficial
Moderate
Lactobacillus rhamnosus LRa05Reduced T Cell ResponsivenessBeneficial
Moderate
Lactobacillus rhamnosus lysate powderEnhanced Dendritic Cell-T Cell InteractionBeneficial
Moderate
Lactobacillus rhamnosus MAK79L08REnhanced Dendritic Cell-T Cell InteractionBeneficial
Moderate
Lactobacillus rhamnosus PXN 54Modulated Dendritic Cell FunctionBeneficial
Moderate
Lactobacillus rhamnosus PXN 54Reduced T Cell ResponsivenessBeneficial
Moderate
Lactobacillus rhamnosus R0011Reduced T Cell ResponsivenessBeneficial
Moderate
Lactobacillus rhamnosus SD-5217Reduced T Cell ResponsivenessBeneficial
Moderate
Lactobacillus rhamnosus UALr-18Reduced T Cell ResponsivenessBeneficial
Moderate
Lactobacillus rhamnosus VPro 11Beneficial Clinical EffectsBeneficial
Moderate
L. casei rhamnosusEnhanced Dendritic Cell-T Cell InteractionBeneficial
Moderate
L. casei rhamnosusReduced T Cell ResponsivenessBeneficial
Moderate
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