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Abstract

In this study, two Lactobacillus strains (L. rhamnosus LA68 and L. plantarum WCFS1) were evaluated for their effects on high fat diet induced pathology in mice. The aim was to determine whether the administration of lactic acid bacteria had beneficial effects on ameliorating pathology. C57BL/6 mice fed a high fat diet were orally administered with the Lactobacillus strains. Both the metabolic and immunological parameters were analyzed. The administration of both of the strains had beneficial effects on mouse weight, serum cholesterol, TNF-α levels and liver histology. LA68 lowered the total cholesterol and HDL levels more prominently, whereas WCFS1 was more potent in lowering the TG and LDL levels. Leptin and adiponectin levels were increased in all experimental groups to different extents. The administration of L. plantarum WCFS1 led to a marked increase in leptin levels, as well as an increase in CD3+CD4+ and CD3+CD8+ cells, and a decrease of CD25+ cells, and had a lowering effect on IL-6 production and cell metabolic activity. In conclusion, active administration of both Lactobacillus strains had a positive effect on HFD-induced pathology. Although both of the tested strains had beneficial effects, oral administration of WCFS1 increased leptin levels and had a more prominent immunomodulatory effect, which should be taken into consideration in case of humane usage.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus plantarum DSM 6596Improved Liver HistologyBeneficial
Large
Lactobacillus plantarum DSM 6596Increased Leptin LevelsBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced CD25+ CellsBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced Cellular Metabolic ActivityBeneficial
Small
Lactobacillus plantarum DSM 6596Reduced Interleukin-6 ProductionBeneficial
Small
Lactobacillus plantarum DSM 6596Reduced LDL CholesterolBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced Serum Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced TNF-α LevelsBeneficial
Small
Lactobacillus plantarum DSM 6596Reduced Triglyceride LevelsBeneficial
Moderate
Lactobacillus plantarum KABP™-061Improved ImmunomodulationBeneficial
Moderate
Lactobacillus plantarum KABP™-061Increased Leptin LevelsBeneficial
Moderate
Lactobacillus plantarum R1012Improved Liver HistologyBeneficial
Large
Lactobacillus plantarum R1012Increased Leptin LevelsBeneficial
Moderate
Lactobacillus plantarum R1012Reduced CD25+ CellsBeneficial
Moderate
Lactobacillus plantarum R1012Reduced IL-6 ProductionBeneficial
Moderate
Lactobacillus plantarum R1012Reduced LDL Cholesterol LevelsBeneficial
Large
Lactobacillus plantarum R1012Reduced Serum CholesterolBeneficial
Large
Lactobacillus plantarum Rosell-AIncreased Leptin LevelsBeneficial
Moderate
Lactobacillus plantarum Rosell-AReduced CD25+ CellsBeneficial
Moderate
Lactobacillus plantarum Rosell-AReduced Cellular Metabolic ActivityBeneficial
Small
Lactobacillus plantarum Rosell-AReduced Interleukin-6 ProductionBeneficial
Small
Lactobacillus plantarum Rosell-AReduced LDL CholesterolBeneficial
Moderate
Lactobacillus plantarum Rosell-AReduced Triglyceride LevelsBeneficial
Moderate
Lactobacillus plantarum WCFS1Increased CD3+CD4+ Cell CountsBeneficial
Moderate
Lactobacillus plantarum WCFS1Increased CD3+CD8+ Cell CountsBeneficial
Moderate
Lactobacillus plantarum WCFS1Increased Leptin LevelsBeneficial
Moderate
Lactobacillus plantarum WCFS1Reduced CD25+ CellsBeneficial
Moderate
Lactobacillus plantarum WCFS1Reduced IL-6 ProductionBeneficial
Moderate
Lactobacillus plantarum WCFS1Reduced Low-Density Lipoprotein LevelBeneficial
Large
Lactobacillus plantarum WCFS1Reduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum WCFS1Reduced Triglyceride LevelsBeneficial
Moderate
Lactobacillus rhamnosus DSM33560Increased Leptin LevelsBeneficial
Moderate
Lactobacillus rhamnosus DSM33560Reduced HDL LevelsBeneficial
Moderate
Lactobacillus rhamnosus DSM33560Reduced Total Cholesterol LevelsBeneficial
Moderate
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