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Abstract

To elucidate the anti-obesity effect of Lactobacillus rhamnosus LRa05 through the analysis of gut microbiota and liver metabolomics, we investigated changes in gut microbiota and liver metabolomic phenotypes in mice by 16S ribosomal RNA gene sequencing and ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. C57BL/6J male mice were orally administered with LRa05 for 8 weeks. Body weight, serum lipid levels, and the lipid accumulation of liver cells and epididymal fat tissues in the mice fed with a high-fat diet were inhibited after treatment with LRa05 at 1 × 109 CFU per day per mouse. LRa05 also reshaped the gut microbiota, reduced the abundance of the pro-pathogen bacterial Streptococcus, suppressed blood and liver glucose content, and promoted liver carbohydrate and energy metabolism. Moreover, Intestinimonas and palmitoyl ethanolamide exhibited a positive correlation, whereas Enterorhabdus and vitamin B2 showed a negative correlation. Therefore, LRa05 can potentially be used as an anti-obesity probiotic in further interventions.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus rhamnosus CLR1505Improved Gut Microbiome CompositionBeneficial
Moderate
Lactobacillus rhamnosus CLR1505Reduced Blood Glucose LevelsBeneficial
Moderate
Lactobacillus rhamnosus CLR1505Reduced Body WeightBeneficial
Moderate
Lactobacillus rhamnosus CLR1505Reduced Epididymal Fat Tissue AccumulationBeneficial
Moderate
Lactobacillus rhamnosus CLR1505Reduced Hepatic Lipid AccumulationBeneficial
Moderate
Lactobacillus rhamnosus CLR1505Reduced Lipid LevelsBeneficial
Moderate
Lactobacillus rhamnosus CRL 1505Altered Gut MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus CRL 1505Reduced Hepatic Lipid AccumulationBeneficial
Moderate
Lactobacillus rhamnosus DSM 6594Altered Gut MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus DSM 6594Reduced Lipid LevelsBeneficial
Moderate
Lactobacillus rhamnosus DSM 6594Reduced Weight GainBeneficial
Large
Lactobacillus rhamnosus LR04Balanced Gut MicrobiotaBeneficial
Large
Lactobacillus rhamnosus LR04Improved Lipid ProfileBeneficial
Large
Lactobacillus rhamnosus LR04Reduced Blood Glucose LevelsBeneficial
Moderate
Lactobacillus rhamnosus LR04Reduced Body WeightBeneficial
Moderate
Lactobacillus rhamnosus LR05Altered Gut MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus LR05Improved Lipid LevelsBeneficial
Large
Lactobacillus rhamnosus LR05Reduced Abundance of Pro-Pathogenic BacteriaBeneficial
Moderate
Lactobacillus rhamnosus LR05Reduced Weight GainBeneficial
Large
Lactobacillus rhamnosus LR06Altered Gut MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus LR06Reduced Blood Glucose LevelsBeneficial
Moderate
Lactobacillus rhamnosus LR06Reduced Weight GainBeneficial
Large
Lactobacillus rhamnosus LRa05Improved Carbohydrate MetabolismBeneficial
Moderate
Lactobacillus rhamnosus LRa05Improved Gut Microbiome CompositionBeneficial
Moderate
Lactobacillus rhamnosus LRa05Reduced Blood Glucose LevelsBeneficial
Moderate
Lactobacillus rhamnosus LRa05Reduced Lipid AccumulationBeneficial
Large
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