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Lactobacillus sakei ADM14 Induces Anti-Obesity Effects and Changes in Gut Microbiome in High-Fat Diet-Induced Obese Mice

  • 2020-11-30
  • Nutrients 12(12)
    • Sung-Min Won
    • Siyu Chen
    • Seo Yeon Lee
    • Kyung Eun Lee
    • K. Park
    • J. Yoon

Abstract

The aim of our study was to evaluate the anti-obesity effects of Lactobacillus sakei (L. sakei) ADM14 administration in a high-fat diet-induced obese mouse model and the resulting changes in the intestinal microbiota. Prior to in vivo testing, L. sakei ADM14 was shown to inhibit adipogenesis through in vitro test and genetic analysis. Subsequently, mice were orally administered 0.85% saline supplemented or not with L. sakei ADM14 to high-fat diet group and normal diet group daily. The results showed that administration of L. sakei ADM14 reduced weight gain, epididymal fat expansion, and total blood cholesterol and glucose levels, and significantly decreased expression of lipid-related genes in the epididymal fat pad. Administration of L. sakei ADM14 showed improvement in terms of energy harvesting while restoring the Firmicutes to Bacteroidetes ratio and also increased the relative abundance of specific microbial taxa such as Bacteroides faecichinchillae and Alistipes, which are abundant in non-obese people. L. sakei ADM14 affected the modulation of gut microbiota, altered the strain profile of short-chain fatty acid production in the cecum and enhanced the stimulation of butyrate production. Overall, L. sakei ADM14 showed potential as a therapeutic probiotic supplement for metabolic disorders, confirming the positive changes of in vivo indicators and controlling gut microbiota in a high-fat diet-induced obese mouse model.

Keywords: Lactobacillus sakei; anti-obesity; gut microbiome; probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus sakeiImproved Blood Glucose LevelsBeneficial
Moderate
Lactobacillus sakeiImproved Energy LevelsBeneficial
Moderate
Lactobacillus sakeiIncreased Butyrate ProductionBeneficial
Moderate
Lactobacillus sakeiReduced Epididymal Fat MassBeneficial
Large
Lactobacillus sakeiReduced Expression of Lipid-Related Genes in Epididymal FatBeneficial
Moderate
Lactobacillus sakeiReduced Firmicutes/Bacteroidetes RatioBeneficial
Moderate
Lactobacillus sakeiReduced Total Blood CholesterolBeneficial
Moderate
Lactobacillus sakeiReduced Weight GainBeneficial
Large
Lactobacillus sakei proBio65Improved Blood Glucose LevelsBeneficial
Moderate
Lactobacillus sakei proBio65Increased Abundance of Beneficial MicrobesBeneficial
Moderate
Lactobacillus sakei proBio65Increased Butyrate ProductionBeneficial
Moderate
Lactobacillus sakei proBio65Reduced Epididymal Fat MassBeneficial
Large
Lactobacillus sakei proBio65Reduced Expression of Lipid-Related Genes in Epididymal FatBeneficial
Moderate
Lactobacillus sakei proBio65Reduced Firmicutes/Bacteroidetes RatioBeneficial
Moderate
Lactobacillus sakei proBio65Reduced Total Blood CholesterolBeneficial
Moderate
Lactobacillus sakei proBio65Reduced Weight GainBeneficial
Large
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