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Abstract

Lactobacillus strains with fine probiotic properties are continuously needed in the laying hen industry to improve the animals' gut health and production performance. In this study, we isolated 57 Lactobacillus strains from the gut microbiota of 17 different chicken breeds in China. We characterized the probiotic features of these isolates, and evaluated the effects of a selected strain, Lactobacillus salivarius CML352, on the production performance and gut health of the late-phase laying hens. The results showed that the isolates varied much in probiotic properties, among which L. salivarius CML352 displayed high acid and bile salt tolerance, high hydrophobicity, auto-aggregation, and antibacterial activities. Whole genome sequencing analysis showed that CML352 was closely related to a strain isolated from human fecal samples, but had different functional potentials. Dietary supplementary of L. salivarius CML352 significantly reduced the Firmicutes to Bacteroidetes ratio, increased the expression of Muc-2, and decreased the expression of MyD88, IFN-γ, and TLR-4. Furthermore, strain CML352 reduced the birds' abdominal fat deposition, and improved egg quality. Taken together, this study indicated that the newly isolated L. salivarius strain might be a worthy probiotic with positive impacts on the intestinal health and production performance of late-phase laying hens.

Keywords: Lactobacillus salivarius; egg quality; gut microbiota; intestinal health; laying hens.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus SalivariusImproved Egg QualityBeneficial
Moderate
Lactobacillus SalivariusIncreased MUC-2 ExpressionBeneficial
Moderate
Lactobacillus SalivariusReduced Firmicutes/Bacteroidetes RatioBeneficial
Moderate
Lactobacillus SalivariusReduced Visceral FatBeneficial
Moderate
Lactobacillus salivarius SD-5208Improved Egg QualityBeneficial
Moderate
Lactobacillus salivarius SD-5208Improved Intestinal FunctionBeneficial
Moderate
Lactobacillus salivarius SD-5208Increased MUC-2 ExpressionBeneficial
Moderate
Lactobacillus salivarius SD-5208Reduced Firmicutes/Bacteroidetes RatioBeneficial
Moderate
Lactobacillus salivarius SD-5208Reduced IFN-γ ExpressionBeneficial
Moderate
Lactobacillus salivarius SD-5208Reduced MyD88 ExpressionBeneficial
Moderate
Lactobacillus salivarius SD-5208Reduced TLR4 ExpressionBeneficial
Moderate
Lactobacillus salivarius SD-5208Reduced Visceral FatBeneficial
Moderate
Lactobacillus salivarius SD-5851Improved Egg QualityBeneficial
Moderate
Lactobacillus salivarius SD-5851Improved Intestinal FunctionBeneficial
Moderate
Lactobacillus salivarius SD-5851Reduced Visceral FatBeneficial
Moderate
Lactobacillus salivarius UALb-07Improved Egg QualityBeneficial
Moderate
Lactobacillus salivarius UALb-07Increased MUC-2 ExpressionBeneficial
Moderate
Lactobacillus salivarius UALb-07Reduced Firmicutes/Bacteroidetes RatioBeneficial
Moderate
Lactobacillus salivarius UALb-07Reduced IFN-γ ExpressionBeneficial
Moderate
Lactobacillus salivarius UALb-07Reduced MyD88 ExpressionBeneficial
Moderate
Lactobacillus salivarius UALb-07Reduced TLR4 ExpressionBeneficial
Moderate
Lactobacillus salivarius UALb-07Reduced Visceral FatBeneficial
Moderate
Lactobacillus salivarius UALs07Improved Egg QualityBeneficial
Moderate
Lactobacillus salivarius UALs07Increased MUC-2 ExpressionBeneficial
Moderate
Lactobacillus salivarius UALs07Reduced Firmicutes/Bacteroidetes RatioBeneficial
Moderate
Lactobacillus salivarius UALs07Reduced IFN-γ ExpressionBeneficial
Moderate
Lactobacillus salivarius UALs07Reduced MyD88 ExpressionBeneficial
Moderate
Lactobacillus salivarius UALs07Reduced TLR4 ExpressionBeneficial
Moderate
Lactobacillus salivarius UALs07Reduced Visceral FatBeneficial
Moderate
Lactobacillus salivarius UALs07 UASImproved Egg QualityBeneficial
Moderate
Lactobacillus salivarius UALs07 UASImproved Gastrointestinal HealthBeneficial
Large
Lactobacillus salivarius UALs07 UASReduced Visceral FatBeneficial
Moderate
Lactobacillus salivarius VPro 15Improved Intestinal Mucosal ImmunityBeneficial
Moderate
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