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Lactobacillus salivarius Isolated from Patients with Rheumatoid Arthritis Suppresses Collagen-Induced Arthritis and Increases Treg Frequency in Mice.

  • 2016-12
  • Journal of Interferon & Cytokine Research 36(12)
    • Xiaofei Liu
    • Juan Zhang
    • Q. Zou
    • Bing Zhong
    • Heng Wang
    • Fangxiang Mou
    • Like Wu
    • Yongfei Fang


Previously, we demonstrated that Lactobacillus salivarius was more abundant in patients with rheumatoid arthritis (RA), an inflammatory autoimmune disease wherein the gut microbiota is altered, than in healthy individuals. However, the effect of L. salivarius in RA is unclear. Hence, we investigated the effect of L. salivarius isolated from patients with RA on collagen-induced arthritis (CIA) in mice. L. salivarius UCC118 or L. plantarum WCFS1 isolated from patients with RA was administered orally for 5 weeks, starting from 2 weeks before the induction of arthritis in DBA/1 mice. Clinical score progression, histological changes, serum cytokine concentrations, and the proportion of interleukin (IL)-17-producing T cells [T helper 17 (Th17)] and regulatory T cells (Tregs) in the spleen were evaluated. Bone erosion was evaluated by micro-computed tomography. CIA mice treated with either L. salivarius or L. plantarum showed lower arthritis scores, milder synovial infiltration, and less bone erosion when compared with phosphate-buffered, saline-treated CIA mice. Administration of L. salivarius and L. plantarum reduced the Th17 cell fraction and increased the Treg fraction. L. salivarius-treated CIA mice displayed a significant increase in serum anti-inflammatory IL-10 levels. Thus, pretreatment with L. salivarius could significantly improve CIA in mice and may help alleviate RA in a clinical setting.

Keywords: Lactobacillus salivarius; Th17 cells; collagen-induced arthritis; regulatory T cell; rheumatoid arthritis.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus salivarius UCC118Increased Interleukin-10 LevelsBeneficial
Lactobacillus salivarius UCC118Increased Treg Cell FractionBeneficial
Lactobacillus salivarius UCC118Reduced Arthritis ScoreBeneficial
Lactobacillus salivarius UCC118Reduced Bone ErosionBeneficial
Lactobacillus salivarius UCC118Reduced Synovial InfiltrationBeneficial
Lactobacillus salivarius UCC118Reduced Th17 Cell FractionBeneficial
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