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Lactobacillus salivarius UCC118™ Dampens Inflammation and Promotes Microbiota Recovery to Provide Therapeutic Benefit in a DSS-Induced Colitis Model

  • 2022-07-09
  • Microorganisms 10(7)
    • N. Iyer
    • Michelle A Williams
    • A. O’Callaghan
    • E. Dempsey
    • R. Cabrera-Rubio
    • Mathilde Raverdeau
    • F. Crispie
    • P. Cotter
    • S. Corr


The use of probiotics such as Lactobacillus and Bifidobacterium spp. as a therapeutic against inflammatory bowel disease (IBD) is of significant interest. Lactobacillus salivarus strain UCC118TM is a commensal that has been shown to possess probiotic properties in vitro and anti-infective properties in vivo. However, the usefulness of UCC118 TM as a therapeutic against colitis remains unclear. This study investigates the probiotic potential of Lactobacillus salivarius, UCC118™ in a mouse model of colitis. DSS-induced colitis was coupled with pre-treatment or post-treatment with UCC118TM by daily oral gavage. In the pre-treatment model of colitis, UCC118TM reduced the severity of the disease in the early stages. Improvement in disease severity was coupled with an upregulation of tissue IL-10 levels and increased expression of macrophage M2 markers. This anti-inflammatory activity of UCC118TM was further confirmed in vitro, using a model of LPS-treated bone marrow-derived macrophages. Taken together, these results suggest that UCC118TM may promote the resolution of inflammation. This was supported in a mouse model of established DSS-induced colitis whereby UCC118TM treatment accelerated recovery, as evidenced by weight, stool, histological markers and the recovery of microbiome-associated dysbiosis with an increased abundance of beneficial commensal species. These results demonstrate the potential of Lactobacillus salivarius UCC118TM as a probiotic-based therapeutic strategy to promote health through the upregulation of anti-inflammatory IL-10 and protect against dysbiosis during IBD.

Keywords: colitis; inflammation; microbiota; probiotic.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus SalivariusAccelerated Colitis RecoveryBeneficial
Lactobacillus SalivariusEnhanced Inflammation ResolutionBeneficial
Lactobacillus SalivariusEnhanced M2 Macrophage Marker ExpressionBeneficial
Lactobacillus SalivariusIncreased Anti-Inflammatory Cytokine IL-10Beneficial
Lactobacillus SalivariusRecovered Microbiome-associated DysbiosisBeneficial
Lactobacillus SalivariusReduced Colitis SeverityBeneficial
Lactobacillus salivarius UALs07 UASAccelerated Colitis RecoveryBeneficial
Lactobacillus salivarius UALs07 UASEnhanced M2 Macrophage Marker ExpressionBeneficial
Lactobacillus salivarius UCC118Improved Recovery From ColitisBeneficial
Lactobacillus salivarius UCC118Increased Interleukin-10 LevelsBeneficial
Lactobacillus salivarius UCC118Reduced Colitis SeverityBeneficial
Lactobacillus salivarius UCC118Reduced DysbiosisBeneficial
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