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Lactococcus lactis subsp. cremoris FC triggers IFN-γ production from NK and T cells via IL-12 and IL-18.

  • 2012-12
  • International Immunopharmacology 14(4)
    • A. Kosaka
    • Huimin Yan
    • S. Ohashi
    • Yayoi Gotoh
    • Ami Sato
    • H. Tsutsui
    • T. Kaisho
    • T. Toda
    • N. Tsuji

Abstract

Lactic acid bacteria (LAB) benefit health as probiotics in a strain-dependent way. In this study, we investigated the immunomodulatory effects of Lactococcus lactis subsp. cremoris FC (LcFC) on dendritic cells (DCs), natural killer (NK) cells and T cells. LcFC induced the production of cytokines such as IL-10, IL-12, IL-6 and TNF-α from murine bone marrow DCs (BMDCs) via MyD88-dependent pathway. In comparison with the type strain L. lactis subsp. cremoris ATCC 19257, LcFC induced particularly high production of IL-12 while induction of IL-6 was moderate. Consequently, LcFC triggered IFN-γ production in splenic NK, CD8(+), and CD4(+) cells. Most prominent effect of LcFC on IFN-γ production was observed in NK cells, followed by CD8(+) cells, which was completely inhibited by combination of neutralizing anti-IL-12 and anti-IL-18 mAbs. Moreover, oral administration of LcFC enhanced the production of IFN-γ and IL-10 from splenocytes of treated mice. These findings suggest that this LAB strain is an efficient activator of protective cellular immunity via stimulation of myeloid cells including DCs.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactococcus cremorisEnhanced Interferon Gamma ProductionBeneficial
Moderate
Lactococcus cremorisImproved Cellular Immune ResponseBeneficial
Moderate
Lactococcus cremorisIncreased Cytokine ProductionBeneficial
Large
Lactococcus cremorisIncreased IL-10 ProductionBeneficial
Moderate
Lactococcus cremoris VPro 41Enhanced IFN-γ ProductionBeneficial
Large
Lactococcus cremoris VPro 41Enhanced Interleukin-10 ProductionBeneficial
Moderate
Lactococcus cremoris VPro 41Increased Interleukin-12 ProductionBeneficial
Large
Lactococcus lactis subsp. lactisEnhanced Interferon Gamma ProductionBeneficial
Moderate
Lactococcus lactis subsp. lactisEnhanced Interleukin-10 ProductionBeneficial
Moderate
Lactococcus lactis subsp. lactisImproved Cellular ImmunityBeneficial
Large
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