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Limosilactobacillus reuteri in Health and Disease

  • 2022-02-28
  • Microorganisms 10(3)
    • Jumana Abuqwider
    • Mohammad Altamimi
    • G. Mauriello


Limosilactobacillus reuteri is a microorganism with valuable probiotic qualities that has been widely employed in humans to promote health. It is a well-studied probiotic bacterium that exerts beneficial health effects due to several metabolic mechanisms that enhance the production of anti-inflammatory cytochines and modulate the gut microbiota by the production of antimicrobial molecules, including reuterin. This review provides an overview of the data that support the role of probiotic properties, and the antimicrobial and immunomodulatory effects of some L. reuteri strains in relation to their metabolite production profile on the amelioration of many diseases and disorders. Although the results discussed in this paper are strain dependent, they show that L. reuteri, by different mechanisms and various metabolites, may control body weight and obesity, improve insulin sensitivity and glucose homeostasis, increase gut integrity and immunomodulation, and attenuate hepatic disorders. Gut microbiota modulation by ingesting probiotic L. reuteri strains could be a promising preventative and therapeutic approach against many diseases and disorders.

Keywords: glucose homeostasis; hepatic disease; obesity.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Limosilactobacillus reuteri 1E1Attenuated Hepatic DisordersBeneficial
Limosilactobacillus reuteri 1E1Improved Gut IntegrityBeneficial
Limosilactobacillus reuteri 1E1Improved ImmunomodulationBeneficial
Limosilactobacillus reuteri 1E1Improved Insulin SensitivityBeneficial
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