Lipid-Lowering Effects of Pediococcus acidilactici M76 Isolated from Korean Traditional Makgeolli in High Fat Diet-Induced Obese Mice
- 2014-03-07
- Nutrients 6(3)
- PubMed: 24609135
- DOI: 10.3390/nu6031016
Study Design
- Type
- Randomized Controlled Trial (RCT)
- Population
- Male C57BL/6J mice
- Methods
- Controlled experimental study
- Animal Study
Abstract
The effect of Pediococcus acidilactici M76 (lactic acid bacteria) isolated from makgeolli on mice fed a high fat diet was investigated to clarify the lipid lowering function. C57BL/6J male mice were randomly divided into a normal diet (ND) group, high fat diet (HD) group, HD plus Pediococcus acidilactici DSM 20284 reference strain (PR) group, and HD plus Pediococcus acidilactici M76 strain (PA) groups. The lyophilized PA and PR strain were dissolved in distilled water at a final concentration of 1.25 × 10⁹ cfu/mL and was given orally to animals at a dose of 4 mL/kg body weight for 12 weeks. The PA group had a lower final body weight, adipose tissue weight, and lipid profile than those in the HD group. Additionally, level of ACC, FAS and PPAR-γ, a key lipid synthesis enzyme, was markedly suppressed in the PA compared to those in the HD group. These data suggest that P. acidilactici M76 may exert a lipid-lowering effect in high fat diet-induced obese mice.
Research Insights
The PA group had a lower... lipid profile than those in the HD group.
- Effect
- Beneficial
- Effect size
- Moderate
The PA group had a lower... adipose tissue weight... than those in the HD group.
- Effect
- Beneficial
- Effect size
- Moderate
The PA group had a lower final body weight... than those in the HD group.
- Effect
- Beneficial
- Effect size
- Moderate
The PA group had a lower... lipid profile than those in the HD group.
- Effect
- Beneficial
- Effect size
- Moderate
The PA group had a lower... adipose tissue weight... than those in the HD group.
- Effect
- Beneficial
- Effect size
- Moderate
The PA group had a lower final body weight... than those in the HD group.
- Effect
- Beneficial
- Effect size
- Moderate
The level of ACC, FAS and PPAR-γ, a key lipid synthesis enzyme, was markedly suppressed in the PA compared to those in the HD group.
- Effect
- Beneficial
- Effect size
- Moderate
The PA group had a lower... lipid profile than those in the HD group.
- Effect
- Beneficial
- Effect size
- Moderate
The PA group had a lower final body weight, adipose tissue weight, and lipid profile than those in the HD group.
- Effect
- Beneficial
- Effect size
- Large
The PA group had a lower final body weight... than those in the HD group.
- Effect
- Beneficial
- Effect size
- Moderate