Lipid-Lowering Effects of Pediococcus acidilactici M76 Isolated from Korean Traditional Makgeolli in High Fat Diet-Induced Obese Mice
- 2014-03-07
- Nutrients 6(3)
- Yeon‐jeong Moon
- S. Baik
- Y. Cha
- PubMed: 24609135
- DOI: 10.3390/nu6031016
Abstract
The effect of Pediococcus acidilactici M76 (lactic acid bacteria) isolated from makgeolli on mice fed a high fat diet was investigated to clarify the lipid lowering function. C57BL/6J male mice were randomly divided into a normal diet (ND) group, high fat diet (HD) group, HD plus Pediococcus acidilactici DSM 20284 reference strain (PR) group, and HD plus Pediococcus acidilactici M76 strain (PA) groups. The lyophilized PA and PR strain were dissolved in distilled water at a final concentration of 1.25 × 10⁹ cfu/mL and was given orally to animals at a dose of 4 mL/kg body weight for 12 weeks. The PA group had a lower final body weight, adipose tissue weight, and lipid profile than those in the HD group. Additionally, level of ACC, FAS and PPAR-γ, a key lipid synthesis enzyme, was markedly suppressed in the PA compared to those in the HD group. These data suggest that P. acidilactici M76 may exert a lipid-lowering effect in high fat diet-induced obese mice.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Pediococcus acidilactici | Improved Lipid Profile | Beneficial | Moderate |
| Pediococcus acidilactici | Reduced Adipose Tissue Weight | Beneficial | Moderate |
| Pediococcus acidilactici | Reduced Body Weight | Beneficial | Moderate |
| Pediococcus acidilactici KABP™-021 | Improved Lipid Profile | Beneficial | Moderate |
| Pediococcus acidilactici KABP™-021 | Reduced Adipose Tissue Weight | Beneficial | Moderate |
| Pediococcus acidilactici KABP™-021 | Reduced Body Weight | Beneficial | Moderate |
| Pediococcus acidilactici MAK92P26A | Improved Lipid Profile | Beneficial | Moderate |
| Pediococcus acidilactici MAK92P26A | Reduced Adipose Tissue Weight | Beneficial | Moderate |
| Pediococcus acidilactici MAK92P26A | Reduced Body Weight | Beneficial | Moderate |
| Pediococcus acidilactici MAK92P26A | Reduced Lipid Synthesis Enzyme Levels | Beneficial | Moderate |
| Pediococcus acidilactici R1001 | Improved Lipid Profile | Beneficial | Moderate |
| Pediococcus acidilactici R1001 | Reduced Adipose Tissue | Beneficial | Large |
| Pediococcus acidilactici R1001 | Reduced Body Weight | Beneficial | Moderate |
| Pediococcus acidilactici R1001 | Reduced Lipid Synthesis Enzyme Levels | Beneficial | Moderate |
| Pediococcus acidilactici VPro29 | Improved Lipid Profile | Beneficial | Moderate |
| Pediococcus acidilactici VPro29 | Reduced Adipose Tissue | Beneficial | Large |
| Pediococcus acidilactici VPro29 | Reduced Body Weight | Beneficial | Moderate |