Skip to main content

Long-Term Diet Supplementation with Lactobacillus paracasei K71 Prevents Age-Related Cognitive Decline in Senescence-Accelerated Mouse Prone 8

  • 2018-06-13
  • Nutrients 10(6)
    • H. M. Corpuz
    • Saki Ichikawa
    • Misa Arimura
    • Toshihiro Mihara
    • T. Kumagai
    • Takakazu Mitani
    • Soichiro Nakamura
    • S. Katayama


This study aimed to assess the suppressive effect of long-term diet supplementation with Lactobacillus strains on cognitive decline in the senescence-accelerated mouse prone 8 (SAMP8) model. For 43 weeks, fourteen-week-old female SAMP8 mice were fed a standard diet containing 0.05% (w/w) Lactobacillus casei subsp. casei 327 (L. 327) or Lactobacillus__paracasei K71 (L. K71) derived from rice grains and sake lees, respectively. SAMP8 mice that were fed a L. K71-supplemented diet had better cognitive performance compared with the control and L. 327 groups in the Barnes maze and passive avoidance tests. An ELISA analysis revealed that the levels of serotonin were elevated in the serum and brain tissue of L. K71-fed mice. The protein expression levels of brain-derived neurotrophic factor (BDNF), cAMP response element binding protein (CREB), and phosphorylated CREB were evaluated using western blot. Long-term administration of L. K71 resulted in increased protein expression of BDNF and CREB phosphorylation in the hippocampus. These results suggest that prolonged intake of a diet supplemented with a Lactobacillus strain derived from sake lees may prevent age-dependent cognitive decline by upregulating BDNF expression in the hippocampus.

Keywords: Lactobacillus paracasei; brain-derived neurotrophic factor; cognitive dysfunction; probiotics; serotonin.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus paracasei 431Enhanced Brain-Derived Neurotrophic Factor LevelsBeneficial
Lactobacillus paracasei 431Improved Cognitive PerformanceBeneficial
Lactobacillus paracasei 431Increased Serotonin LevelsBeneficial
⬆ Back to top
Supplement Research and Comparison Website: evidence-based information about supplements, their benefits, potential risks, and their efficacy.
Receive updates about our products, services, sales, and special offers. Unsubscribe anytime. See our Privacy Policy for details on how we handle your information.

Join Our Community

Use to get in touch.