Mechanism and research progress of MAPK signaling pathway in myocardial fibrosis.
- 2025-11-21
- Frontiers in cardiovascular medicine 12
- Jinqiao Wu
- Min Chen
- Ze Peng
- Yao Sun
- Juan Jin
- PubMed: 41357083
- DOI: 10.3389/fcvm.2025.1667568
Study Design
- Type
- Review
Myocardial fibrosis (MF) is a hallmark pathological outcome of many cardiovascular diseases and a key component of cardiac remodeling. The p38 MAPK, JNK, and ERK signaling pathways are central to this process. This review summarizes the roles and interactions of these factors in MF and identifies relevant drug and non-pharmacological therapies targeting these pathways.