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A meta-analysis of four randomised controlled trials of varying methodological quality, involving 304 children aged 1-48 months, showed that Lactobacillus acidophilus LB (LB) reduced the duration of diarrhoea in hospitalised, but not outpatient, children compared with a placebo. The chance of a cure on day three was similar in both groups, but LB increased the chance of cure on day four.

Conclusion: There is limited evidence to recommend LB for treating paediatric diarrhoea.

Keywords: Diarrhoea; Microbiota; Probiotics; RCT; Systematic review.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus LBImproved Cure Rate on Day FourBeneficial
Lactobacillus LBReduced Duration of Hospitalized Diarrhea in ChildrenBeneficial
Lactobacillus LBUnchanged Duration of Diarrhoea in Outpatient ChildrenNeutral
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