Metabolic and clinical responses to Bunium Persicum (black caraway) supplementation in overweight and obese patients with type 2 diabetes: a double-blind, randomized placebo-controlled clinical trial.

2020-08-26
Nutrition & metabolism 17(1)
- Saber Jafari-Maskouni
- Mansour Shahraki
- Milad Daneshi-Maskooni
- Alireza Dashipour
- Ali Shamsi-Goushki
- Zinat Mortazavi

PubMed: 32863846
DOI: 10.1186/s12986-020-00494-4

Study Design

Type: Randomized Controlled Trial (RCT)
Sample size: n = 60
Population: 60 overweight and obese patients with type 2 diabetes mellitus (T2DM)
Methods: Randomized, placebo-controlled; 1000 mg capsule 2 times/day with meals for 8 weeks
Duration: 8 weeks
Funding: Unclear

Background

Diabetes mellitus is the most common metabolic disorder worldwide. We aimed to determine the metabolic and clinical responses to Bunium Persicum (Black Caraway) supplementation in overweight and obese patients with T2DM.

Methods

Participant recruitment took place in the diabetic clinic of Bu-Ali hospital in Zahedan. Due to the eligibility criteria, 60 participants were randomly placed into two groups, namely placebo (n = 30) and BP (n = 30). The supplementation was considered one 1000 mg capsule 2 times /day BP by meals (lunch and dinner) for 8 weeks. Physical activity levels, dietary intakes, anthropometric measurements [weight, height, and waist circumference], glycemic indices [fasting blood glucose (FBG) and insulin (FBI)], blood lipids [triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c)], and serum nesfatin-1 level were determined. Homeostasis model assessment-insulin resistance (HOMA-IR), Quantitative insulin sensitivity checks index (QUICKI), and Body Mass Index (BMI) were computed.

Results

In comparison with placebo, BP significantly decreased FBG, HOMA-IR, and BMI (P < 0.05). The differences in the FBI, QUICKI, TG, TC, LDL, HDL, WC, and Nesfatin-1 were not significant (P > 0.05).

Conclusion

BP supplementation improved serum glucose indices and BMI among overweight and obese T2DM patients. Further trials are needed to confirm results.

Trial registration

Iranian Registry of Clinical Trials (IRCT), IRCT20181207041876N1, Registered 18/01/2019, https://irct.ir/trial/35752.

Research Insights

Black Caraway→Improved Insulin Sensitivity
BP significantly decreased FBG, HOMA-IR, and BMI (P < 0.05).
Effect
Beneficial
Effect size
Moderate
Dose
1000 mg capsule 2 times /day
Black Caraway→Reduced Body Mass Index
BP significantly decreased FBG, HOMA-IR, and BMI (P < 0.05).
Effect
Beneficial
Effect size
Moderate
Dose
1000 mg capsule 2 times /day
Black Caraway→Reduced Fasting Blood Glucose Levels
BP significantly decreased FBG, HOMA-IR, and BMI (P < 0.05).
Effect
Beneficial
Effect size
Moderate
Dose
1000 mg capsule 2 times /day