Microbial production of vitamin B5: current status and prospects.
- 2022-10-09
- Critical reviews in biotechnology 43(8)
- Kuo Zhao
- Heng Tang
- Bo Zhang
- Shuping Zou
- Zhiqiang Liu
- Yuguo Zheng
- PubMed: 36210178
- DOI: 10.1080/07388551.2022.2104690
Study Design
- Type
- Review
Vitamin B5, also called D-pantothenic acid (D-PA), is a necessary micronutrient that plays an essential role in maintaining the physiological function of an organism. It is widely used in: food, medicine, feed, cosmetics, and other fields. Currently, the production of D-PA in industry heavily relies on chemical processes and enzymatic catalysis. With an increasing demand on the market, replacing chemical-based production of D-PA with microbial fermentation utilizing renewable resources is necessary. In this review, the physiological role and applications of D-PA were firstly introduced, after which the biosynthesis pathways and enzymes will be summarized. Subsequently, a series of cell factory development strategies for excessive D-PA production are analyzed and discussed. Finally, the prospect of microbial production of D-PA production has been prospected.