Microbiome-Based Therapeutics for Insomnia.
- 2024-12-09
- International journal of molecular sciences 25(23)
- Chenyu Li
- Sizhe Chen
- Yun Wang
- Qi Su
- PubMed: 39684918
- DOI: 10.3390/ijms252313208
Insomnia poses considerable risks to both physical and mental health, leading to cognitive impairment, weakened immune function, metabolic dysfunction, cardiovascular issues, and reduced quality of life. Given the significant global increase in insomnia and the growing scientific evidence connecting gut microbiota to this disorder, targeting gut microbiota as an intervention for insomnia has gained popularity. In this review, we summarize current microbiome-based therapeutics for insomnia, including dietary modifications; probiotic, prebiotic, postbiotic, and synbiotic interventions; and fecal microbiota transplantation. Moreover, we assess the capabilities and weaknesses of these technologies to offer valuable insights for future studies.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus brevis SBC8803 | Improved Sleep Quality | Beneficial | Moderate |