Microbiota modifications in prehabilitation - the next step towards comprehensive preparation for surgery. The scoping review.

2024
Przeglad gastroenterologiczny 19(4)

PubMed: 39810873
DOI: 10.5114/pg.2024.145833

Study Design

Type: Review
Population: surgical patients
Methods: This scoping review highlights the role of microbiota modifications in prehabilitation for surgical patients. It emphasises the importance of optimising gut microbiota through probiotics, synbiotics, and postbiotics to reduce surgical complications, such as surgical site infections (SSIs).

This scoping review highlights the role of microbiota modifications in prehabilitation for surgical patients. It emphasises the importance of optimising gut microbiota through probiotics, synbiotics, and postbiotics to reduce surgical complications, such as surgical site infections (SSIs). The review highlights that gut dysbiosis, worsened by surgery, stress, antibiotics, and poor diet, can lead to increased infection risk and slower recovery. Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery. The review advocates for an individualised approach to prehabilitation, incorporating microbiota modifications based on patient-specific factors and surgery type. However, it also notes the need for further research to standardise therapeutic regimens and confirm the safety and efficacy of these interventions in clinical practice.

Research Insights

Supplement	Dose	Health Outcome	Effect Type	Effect Size	Source
Bifidobacterium bifidum Rosell-71	—	Improved Immune Response	Beneficial	Small	View source Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.
Bifidobacterium bifidum Rosell-71	—	Reduced Postoperative Recovery Time	Beneficial	Small	View source Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.
Bifidobacterium bifidum Rosell-71	—	Reduced Total Infections	Beneficial	Moderate	View source Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.
Bifidobacterium breve Bb-18	—	Improved Immune Response	Beneficial	Small	View source Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.
Bifidobacterium breve Bb-18	—	Improved Recovery Rate	Beneficial	Small	View source Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.
Bifidobacterium breve Bb-18	—	Reduced Recovery Time After Surgery	Beneficial	Small	View source Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.
Bifidobacterium breve Bb-18	—	Reduced Total Infections	Beneficial	Moderate	View source Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.
Bifidobacterium breve Rosell-70	—	Reduced Total Infections	Beneficial	Moderate	View source Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.
Lactobacillus helveticus Rosell-52	—	Reduced Total Infections	Beneficial	Moderate	View source Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.
Lactobacillus plantarum Rosell-1012	—	Reduced Total Infections	Beneficial	Moderate	View source Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.