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Microbiota modifications in prehabilitation - the next step towards comprehensive preparation for surgery. The scoping review.

  • 2025-02-05
  • Przeglad gastroenterologiczny 19(4)
    • Igor Łoniewski
    • Tomasz Banasiewicz
    • Jerzy Sieńko
    • Karolina Skonieczna-Zydecka
    • Ewa Stachowska

Study Design

Type
Review
Population
surgical patients
Methods
This scoping review highlights the role of microbiota modifications in prehabilitation for surgical patients. It emphasises the importance of optimising gut microbiota through probiotics, synbiotics, and postbiotics to reduce surgical complications, such as surgical site infections (SSIs).
This scoping review highlights the role of microbiota modifications in prehabilitation for surgical patients. It emphasises the importance of optimising gut microbiota through probiotics, synbiotics, and postbiotics to reduce surgical complications, such as surgical site infections (SSIs). The review highlights that gut dysbiosis, worsened by surgery, stress, antibiotics, and poor diet, can lead to increased infection risk and slower recovery. Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery. The review advocates for an individualised approach to prehabilitation, incorporating microbiota modifications based on patient-specific factors and surgery type. However, it also notes the need for further research to standardise therapeutic regimens and confirm the safety and efficacy of these interventions in clinical practice.

Research Insights

  • Bifidobacterium bifidum Rosell-71→Improved Immune Response

    Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.

    Effect
    Beneficial
    Effect size
    Small
  • Bifidobacterium bifidum Rosell-71→Reduced Postoperative Recovery Time

    Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.

    Effect
    Beneficial
    Effect size
    Small
  • Bifidobacterium bifidum Rosell-71→Reduced Total Infections

    Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.

    Effect
    Beneficial
    Effect size
    Moderate
  • Bifidobacterium breve Bb-18→Improved Immune Response

    Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.

    Effect
    Beneficial
    Effect size
    Small
  • Bifidobacterium breve Bb-18→Improved Recovery Rate

    Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.

    Effect
    Beneficial
    Effect size
    Small
  • Bifidobacterium breve Bb-18→Reduced Recovery Time After Surgery

    Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.

    Effect
    Beneficial
    Effect size
    Small
  • Bifidobacterium breve Bb-18→Reduced Total Infections

    Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.

    Effect
    Beneficial
    Effect size
    Moderate
  • Bifidobacterium breve Rosell-70→Reduced Total Infections

    Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.

    Effect
    Beneficial
    Effect size
    Moderate
  • Lactobacillus helveticus Rosell-52→Reduced Total Infections

    Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.

    Effect
    Beneficial
    Effect size
    Moderate
  • Lactobacillus plantarum Rosell-1012→Reduced Total Infections

    Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery.

    Effect
    Beneficial
    Effect size
    Moderate
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