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Multifunctional Probiotic and Functional Properties of Lactiplantibacillus plantarum LRCC5314, Isolated from Kimchi

  • 2022-01-28
  • Journal of Microbiology and Biotechnology 32(1)
    • Seokmin Yoon
    • H. Cho
    • YoHan Nam
    • Mi-ri Park
    • Ahyoung Lim
    • Jong-Hwa Kim
    • Jaewoong Park
    • Wonyong Kim

Abstract

In this study, the survival capacity (acid and bile salt tolerance, and adhesion to gut epithelial cells) and probiotic properties (enzyme activity-inhibition and anti-inflammatory activities, inhibition of adipogenesis, and stress hormone level reduction) of Lactiplantibacillus plantarum LRCC5314, isolated from kimchi (Korean traditional fermented cabbage), were investigated. LRCC5314 exhibited very stable survival at ph 2.0 and in 0.2% bile acid with 89.9% adhesion to Caco-2 intestinal epithelial cells after treatment for 2 h. LRCC5314 also inhibited the activities of α-amylase and α-glucosidase, which are involved in elevating postprandial blood glucose levels, by approximately 72.9% and 51.2%, respectively. Treatment of lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with the LRCC5314 lysate decreased the levels of the inflammatory factors nitric oxide, tumor necrosis factor (TNF-α), interleukin (IL)-1β, and interferon-γ by 88.5%, 49.3%, 97.2%, and 99.8%, respectively, relative to those of the cells treated with LPS alone. LRCC5314 also inhibited adipogenesis in differentiating preadipocytes (3T3-L1 cells), showing a 14.7% decrease in lipid droplet levels and a 74.0% decrease in triglyceride levels, as well as distinct reductions in the mRNA expression levels of adiponectin, FAS, PPAR/γ, C/EBPα, TNF-α, and IL-6. Moreover, LRCC5314 reduced the level of cortisol, a hormone with important effect on stress, by approximately 35.6% in H295R cells. L. plantarum LRCC5314 is identified as a new probiotic with excellent in vitro multifunctional properties. Subsequent in vivo studies may further demonstrate its potential as a functional food or pharmabiotic.

Keywords: Lactiplantibacillus plantarum LRCC5314; kimchi; multifunctional properties; probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactiplantibacillus plantarum LP-01Improved Survival CapacityBeneficial
Large
Lactiplantibacillus plantarum LP-01Reduced AdipogenesisBeneficial
Large
Lactiplantibacillus plantarum LP-01Reduced Inflammation LevelsBeneficial
Large
Lactiplantibacillus plantarum LP-01Reduced Postprandial Glucose LevelsBeneficial
Moderate
Lactiplantibacillus plantarum LP-01Reduced Stress Hormone LevelsBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced AdipogenesisBeneficial
Large
Lactiplantibacillus plantarum LP-1Reduced Inflammation LevelsBeneficial
Large
Lactiplantibacillus plantarum LP-1Reduced Postprandial Glucose LevelsBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced Stress Hormone LevelsBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Improved Blood Glucose LevelsBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Improved Gut HealthBeneficial
Large
Lactiplantibacillus plantarum Lp-115Reduced AdipogenesisBeneficial
Large
Lactiplantibacillus plantarum Lp-115Reduced Inflammatory ResponseBeneficial
Large
Lactiplantibacillus plantarum Lp-115Reduced Stress Hormone LevelsBeneficial
Moderate
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