Multimodal insights into adult neurogenesis: An integrative review of multi-omics approaches.
- 2025-02
- Heliyon 11(4)
- Jin Li
- Leyi Huang
- Wenjie Xiao
- Jingyi Kong
- Minghua Hu
- Aihua Pan
- Xiaoxin Yan
- Fulian Huang
- Lily Wan
- PubMed: 40051854
- DOI: 10.1016/j.heliyon.2025.e42668
Study Design
- Type
- Review
- Methods
- In this review, we summarize studies related to genomics, metabolomics, proteomics, epigenomics, transcriptomics, and microbiomics of adult neurogenesis, and then discuss their future research priorities and potential neighborhoods.
Adult neural stem cells divide to produce neurons that migrate to preexisting neuronal circuits in a process named adult neurogenesis. Adult neurogenesis is one of the most exciting areas of current neuroscience, and it may be involved in a range of brain functions, including cognition, learning, memory, and social and behavior changes. While there is a growing number of multi-omics studies on adult neurogenesis, generalized analyses from a multi-omics perspective are lacking. In this review, we summarize studies related to genomics, metabolomics, proteomics, epigenomics, transcriptomics, and microbiomics of adult neurogenesis, and then discuss their future research priorities and potential neighborhoods. This will provide theoretical guidance and new directions for future research on adult neurogenesis.