New functional probiotic Lactobacillus sakei probio 65 alleviates atopic symptoms in the mouse.
- 2008-09
- Journal of Medicinal Food 11(3)
- C. Park
- M. Youn
- Young-mi Jung
- Hong-Joong Kim
- Y. Jeong
- Han-Ki Lee
- H. Kim
- I. Lee
- Soo Won Lee
- K. Kang
- Yong-Ha Park
- PubMed: 18800885
- DOI: 10.1089/jmf.2007.0144
Abstract
The purpose of this study was to investigate the improvement of allergic dermatitis in chemical allergen-induced mice by Lactobacillus sakei probio 65. L. sakei probio-65 was isolated from kimchi, a traditional Korean fermented food. This strain was resistant to gastric acidity, bile, and several antibiotics and possessed antimicrobial activity against several pathogenic microorganisms. To investigate whether the probiotic activity of L. sakei probio 65 was effective for treating allergic dermatitis, the organism was supplied to mice triggered by allergen (1-chloro-2,4-dinitrobenzene). Mice that received L. sakei probio 65 showed a more rapid recovery compared to control mice, as assessed by visual evaluation of the severity of allergic dermatitis and levels of immunoglobulin (Ig) E and interleukin (IL)-4. L. sakei probio 65 exhibited good probiotic properties in vitro and in mice and was effective in reducing allergen-induced skin inflammation through the regulation of both elevated IgE and IL-4 in sensitized mice.
Research Insights
Supplement | Health Outcome | Effect Type | Effect Size |
---|---|---|---|
Lactobacillus sakei proBio65 | Reduced Allergen-Induced Skin Inflammation | Beneficial | Large |
Lactobacillus sakei proBio65 | Reduced Symptoms of Allergic Dermatitis | Beneficial | Moderate |