Nutritional Interventions for Enhancing Female Fertility: A Comprehensive Review of Micronutrients and Their Impact.

2025-01
Nursing research and practice 2025(1)
- Faezeh Mashhadi
- Zahra Sedghi
- Ava Hemmat
- Raha Rivaz
- Fatemeh Roudi

PubMed: 40800608
DOI: 10.1155/nrp/2137328

Study Design

Type: Review

Infertility significantly impacts individuals and society, necessitating effective strategies for its management. Among the various factors influencing female fertility, micronutrients play a crucial role in reproductive health by supporting oocyte quality, hormonal balance, and implantation processes. This narrative review examines the importance of optimal preconception micronutrient intake in enhancing female fertility. By analyzing research from various scientific databases, including PubMed, Google Scholar, and ScienceDirect, spanning from 2000 to April 2024, we highlight the impact of key micronutrients such as folate, vitamin D, iron, selenium, and antioxidants on fertility outcomes. Deficiencies in these nutrients have been associated with impaired ovarian function, disrupted menstrual cycles, and increased risk of pregnancy complications. Given the prevalence of micronutrient inadequacies among women of reproductive age, this review underscores the need for evidence-based nutritional interventions and standardized supplementation guidelines. The findings aim to bridge the gap between research and clinical practice, providing healthcare professionals with insights to optimize fertility care through targeted nutritional strategies.

Research Insights

Iron→Improved Hormonal Balance
microbiota, and antioxidant mechanisms to support fertility.
Effect
Beneficial
Effect size
Small
Iron→Improved Implantation Outcome
microbiota, and antioxidant mechanisms to support fertility.
Effect
Beneficial
Effect size
Small
Iron→Improved Menstrual Cycle Regularity
Deficiencies in these nutrients have been associated with impaired ovarian function, disrupted menstrual cycles, and increased risk of pregnancy complications.
Effect
Beneficial
Effect size
Small
Iron→Improved Oocyte Quality
Deficiencies in these nutrients have been associated with impaired ovarian function, disrupted menstrual cycles, and increased risk of pregnancy complications.
Effect
Beneficial
Effect size
Small
Iron→Reduced Risk of Pregnancy Complications
Deficiencies in these nutrients have been associated with impaired ovarian function, disrupted menstrual cycles, and increased risk of pregnancy complications.
Effect
Beneficial
Effect size
Small
Selenium→Improved Hormonal Balance
microbiota, and antioxidant mechanisms to support fertility.
Effect
Beneficial
Effect size
Small
Selenium→Improved Implantation Outcome
microbiota, and antioxidant mechanisms to support fertility.
Effect
Beneficial
Effect size
Small
Selenium→Improved Menstrual Cycle Regularity
Deficiencies in these nutrients have been associated with impaired ovarian function, disrupted menstrual cycles, and increased risk of pregnancy complications.
Effect
Beneficial
Effect size
Small
Selenium→Improved Oocyte Quality
Deficiencies in these nutrients have been associated with impaired ovarian function, disrupted menstrual cycles, and increased risk of pregnancy complications.
Effect
Beneficial
Effect size
Small
Selenium→Reduced Risk of Pregnancy Complications
Deficiencies in these nutrients have been associated with impaired ovarian function, disrupted menstrual cycles, and increased risk of pregnancy complications.
Effect
Beneficial
Effect size
Small
Vitamin B9→Improved Hormonal Balance
microbiota, and antioxidant mechanisms to support fertility.
Effect
Beneficial
Effect size
Small
Vitamin B9→Improved Implantation Outcome
microbiota, and antioxidant mechanisms to support fertility.
Effect
Beneficial
Effect size
Small
Vitamin B9→Improved Menstrual Cycle Regularity
Deficiencies in these nutrients have been associated with impaired ovarian function, disrupted menstrual cycles, and increased risk of pregnancy complications.
Effect
Beneficial
Effect size
Small
Vitamin B9→Improved Oocyte Quality
Deficiencies in these nutrients have been associated with impaired ovarian function, disrupted menstrual cycles, and increased risk of pregnancy complications.
Effect
Beneficial
Effect size
Small
Vitamin B9→Reduced Risk of Pregnancy Complications
Deficiencies in these nutrients have been associated with impaired ovarian function, disrupted menstrual cycles, and increased risk of pregnancy complications.
Effect
Beneficial
Effect size
Small
Vitamin D→Improved Hormonal Balance
microbiota, and antioxidant mechanisms to support fertility.
Effect
Beneficial
Effect size
Small
Vitamin D→Improved Implantation Outcome
microbiota, and antioxidant mechanisms to support fertility.
Effect
Beneficial
Effect size
Small
Vitamin D→Improved Menstrual Cycle Regularity
Deficiencies in these nutrients have been associated with impaired ovarian function, disrupted menstrual cycles, and increased risk of pregnancy complications.
Effect
Beneficial
Effect size
Small
Vitamin D→Improved Oocyte Quality
Deficiencies in these nutrients have been associated with impaired ovarian function, disrupted menstrual cycles, and increased risk of pregnancy complications.
Effect
Beneficial
Effect size
Small
Vitamin D→Reduced Risk of Pregnancy Complications
Deficiencies in these nutrients have been associated with impaired ovarian function, disrupted menstrual cycles, and increased risk of pregnancy complications.
Effect
Beneficial
Effect size
Small