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Oral administration of Lactobacillus acidophilus induces IL-12 production in spleen cell culture of BALB/c mice bearing transplanted breast tumour.

  • 2010-03-02
  • British Journal of Nutrition 104(2)
    • M. Yazdi
    • M. M. Soltan Dallal
    • Z. Hassan
    • M. Holakuyee
    • S. Agha Amiri
    • M. Abolhassani
    • M. Mahdavi

Abstract

Lactic acid bacteria can affect the maturation of immune cells and their products not only in the gut but also on the systemic immune organs such as lymph nodes and spleen. In the present work, we studied the effects of oral administration of Lactobacillus acidophilus on the immune responses of BALB/c mice bearing transplanted breast tumour. Two groups of female inbred BALB/c mice, each containing nine mice as test and control, were used. The L. acidophilus ATCC4356 strain was inoculated in DeMan-Rogosa-Sharpe broth and cultivated for 24 h at 37 degrees C. Then, it was collected by centrifugation, and was washed and suspended in PBS. Afterwards, 0.5 ml/d of this suspension, which contained 2.7 x 108 colony forming units/ml of bacteria, was orally administered to the mice by gavage, 14 d before tumour transplantation and 30 d after that with 3-d intervals. Similar to the test mice, the control mice received an equal volume of PBS. The results showed that oral administration of L. acidophilus increased the production of IL-12 (P < 0.05) and decreased the level of transforming growth factor beta (P = 0.05) in the splenocyte culture. Moreover, the growth rate of tumour in the test mice decreased (P < 0.01), and the results of delayed-type hypersensitivity assay after 48 h were risen (P < 0.05) in comparison with the controls. Results suggest that daily consumption of L. acidophilus can improve the production of immunomodulatory cytokine IL-12 in the splenocyte culture, which was stimulated by tumour antigen in BALB/c mice bearing transplanted breast tumour. But further studies are needed to find out some other possible mechanisms of this effect.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus acidophilusEnhanced Delayed-Type Hypersensitivity ResponseBeneficial
Large
Lactobacillus acidophilusIncreased Interleukin-12 ProductionBeneficial
Moderate
Lactobacillus acidophilusReduced TGF-beta LevelsBeneficial
Small
Lactobacillus acidophilusReduced Tumor Growth RateBeneficial
Large
Lactobacillus acidophilus HA-122Enhanced Delayed-Type Hypersensitivity ResponseBeneficial
Large
Lactobacillus acidophilus HA-122Increased Interleukin-12 ProductionBeneficial
Moderate
Lactobacillus acidophilus HA-122Reduced Transforming Growth Factor Beta LevelsBeneficial
Small
Lactobacillus acidophilus HA-122Reduced Tumor GrowthBeneficial
Moderate
Lactobacillus acidophilus MAK32L61AEnhanced Delayed-Type Hypersensitivity ResponseBeneficial
Large
Lactobacillus acidophilus MAK32L61AIncreased Interleukin-12 ProductionBeneficial
Moderate
Lactobacillus acidophilus MAK32L61AReduced Transforming Growth Factor Beta LevelsBeneficial
Small
Lactobacillus acidophilus MAK32L61AReduced Tumor GrowthBeneficial
Moderate
Lactobacillus acidophilus NCIMB 30333Enhanced Delayed-Type Hypersensitivity ResponseBeneficial
Large
Lactobacillus acidophilus NCIMB 30333Increased IL-12 ProductionBeneficial
Moderate
Lactobacillus acidophilus NCIMB 30333Reduced Transforming Growth Factor Beta LevelsBeneficial
Small
Lactobacillus acidophilus NCIMB 30333Reduced Tumor GrowthBeneficial
Moderate
Lactobacillus acidophilus R0418Enhanced Delayed-Type Hypersensitivity ResponseBeneficial
Large
Lactobacillus acidophilus R0418Increased IL-12 Production in SplenocytesBeneficial
Moderate
Lactobacillus acidophilus R0418Reduced Transforming Growth Factor Beta LevelsBeneficial
Small
Lactobacillus acidophilus R0418Reduced Tumor GrowthBeneficial
Moderate
Lactobacillus acidophilus SD-5212Improved Delayed-Type Hypersensitivity ResponseBeneficial
Moderate
Lactobacillus acidophilus SD-5212Increased IL-12 ProductionBeneficial
Moderate
Lactobacillus acidophilus SD-5212Reduced Transforming Growth Factor Beta LevelsBeneficial
Small
Lactobacillus acidophilus SD-5212Reduced Tumor GrowthBeneficial
Moderate
Lactobacillus acidophilus UALa01Improved Delayed-Type Hypersensitivity ResponseBeneficial
Moderate
Lactobacillus acidophilus UALa01Increased Interleukin-12 ProductionBeneficial
Moderate
Lactobacillus acidophilus UALa01Reduced TGF-beta LevelsBeneficial
Small
Lactobacillus acidophilus UALa01Reduced Tumor GrowthBeneficial
Moderate
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