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Oral administration of Lactobacillus crispatusM247 to papillomavirus-infected women: results of a preliminary, uncontrolled, open trial.

  • 2021-11
  • Minerva Obstetrics and Gynecology 73(5)
    • F. Di Pierro
    • A. Criscuolo
    • Anna Dei Giudici
    • R. Senatori
    • F. Sesti
    • M. Ciotti
    • E. Piccione


Background: Vaginal microbiotas can be clustered into five different possible categories (CST I to V), according to their bacterial dominance. In CST I, the dominance of Lactobacillus crispatus seems to correlate with better vaginal health and with a lower incidence of sine causa infertility, preterm delivery, bacterial vaginosis, and viral (including human papillomavirus; HPV) infection. According to the same method of classifying the vaginal microbiome, CST IV (non-Lactobacillus-dominated) demonstrates a higher incidence of disorders.

Methods: In an open, non-controlled study, we enrolled 35 HPV-positive women who mostly (N.=24) demonstrated CST IV status, with the other individuals categorized as having either CST III (N.=10) or CST II (N.=1) microbiotas.

Results: After 90 days of oral treatment with a probiotic (L. crispatus M247) we observed a reduction of approximately 70% in HPV positivity and a significant change in CST status with 94% of women now classified as CST I.

Conclusions: Despite the limitations of our study, it is the first demonstration that it is possible to intervene orally with an L. crispatus probiotic to bring about a change in CST status and, in parallel, increased HPV clearance.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus crispatus LBV 88Improved Vaginal Microbiota CompositionBeneficial
Lactobacillus crispatus LBV 88Reduced HPV PositivityBeneficial
Lactobacillus crispatus LBV88Improved Vaginal Microbiota BalanceBeneficial
Lactobacillus crispatus LBV88Reduced HPV PositivityBeneficial
Lactobacillus crispatus LV5 88Improved CST Status to CST IBeneficial
Lactobacillus crispatus LV5 88Reduced HPV PositivityBeneficial
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