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Oral feeding of Lactobacillus bulgaricus N45.10 inhibits the lung inflammation and airway remodeling in murine allergic asthma: Relevance to the Th1/Th2 cytokines and STAT6/T-bet.

  • 2019-07
  • Cellular Immunology 341
    • E. Anatriello
    • M. Cunha
    • J. Nogueira
    • J. Carvalho
    • A. K. Sá
    • M. Miranda
    • H. Castro-Faria-Neto
    • A. Keller
    • F. Aimbire

Abstract

Asthma is a chronic disease with impacts on public health. It affects the airways causing pulmonary inflammation mediated by CD4 T cells type Th2, eosinophilia, mucus hypersecretion, and elevated IgE. The unbalance between cytokines and transcription factors is an important feature in asthma. Probiotics has gaining highlight as a therapy for chronic diseases. Thus, we investigate the Lactobacillus bulgaricus (Lb) effect in murine allergic asthma. BALB/c-mice were sensitized to ovalbumin (OA) on days 0 and 7 and were challenged from day 14-28 with OA. Mice received Lb seven days prior to sensitization and it was kept until day 28. The Lb attenuated the eosinophils infiltration, mucus and collagen secretion, IgE production, pro-inflammatory cytokines, TLR4 expression, GATA3, STAT6 and RORγt in lung. Otherwise, Lb increased the anti-inflammatory cytokines, the T-bet and foxp3. Finally, Lb attenuated the allergic asthma-induced inflammation and airway remodeling by interfering on Th1/Th2 cytokines and STAT6/T-bet transcription factors.

Keywords: Allergic asthma; Cytokines; Mice; Probiotic; Toll-like receptor; Transcriptions factor.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus bulgaricus Lb-87Enhanced T-bet ExpressionBeneficial
Moderate
Lactobacillus bulgaricus Lb-87Increased Anti-Inflammatory Cytokine LevelsBeneficial
Moderate
Lactobacillus bulgaricus Lb-87Increased Foxp3 ExpressionBeneficial
Moderate
Lactobacillus bulgaricus Lb-87Reduced Airway Inflammation ScoreBeneficial
Moderate
Lactobacillus bulgaricus Lb-87Reduced Airway RemodelingBeneficial
Moderate
Lactobacillus bulgaricus Lb-87Reduced Collagen SecretionBeneficial
Moderate
Lactobacillus bulgaricus Lb-87Reduced Eosinophil InfiltrationBeneficial
Moderate
Lactobacillus bulgaricus Lb-87Reduced GATA3 ExpressionBeneficial
Moderate
Lactobacillus bulgaricus Lb-87Reduced Mucus SecretionBeneficial
Moderate
Lactobacillus bulgaricus Lb-87Reduced Pro-inflammatory Cytokine LevelsBeneficial
Moderate
Lactobacillus bulgaricus Lb-87Reduced RORγt ExpressionBeneficial
Moderate
Lactobacillus bulgaricus Lb-87Reduced Serum Immunoglobulin E LevelsBeneficial
Moderate
Lactobacillus bulgaricus Lb-87Reduced STAT6 Gene ExpressionBeneficial
Moderate
Lactobacillus bulgaricus Lb-87Reduced TLR4 ExpressionBeneficial
Moderate
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