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Oral Intake of Lactobacilli Can Be Helpful in Symptomatic Bacterial Vaginosis: A Randomized Clinical Study

  • 2020-02-22
  • Journal of Lower Genital Tract Disease 24(3)
    • Halyna Reznichenko
    • N. Henyk
    • V. Maliuk
    • Tetyana Khyzhnyak
    • Yevhenia Tynna
    • Ihor Filipiuk
    • N. Veresniuk
    • Larysa Zubrytska
    • J. Quintens
    • K. Richir
    • S. Gerasymov

Abstract

Objective: The aim of the study was to explore a role of oral intake of a mixture of 3 Lactobacillus species in recurrence of bacterial vaginosis (BV).

Materials and methods: A phase 2 randomized parallel group prospective placebo-controlled study conducted at 7 clinical centers enrolled 18- to 45-years-old women with recent symptomatic BV cured with metronidazole. Within 48 hours after completion of metronidazole therapy, eligible women received 1 capsule of the verum (5.4 billion Lactobacillus crispatus LMG S-29995, Lactobacillus brevis, and Lactobacillus acidophilus in proportion of 60%, 20%, and 20%, respectively), or the placebo supplement 2 times daily for the first 7 days and 1 time daily for the next 8 to 120 days. The primary outcome measure was the percentage of recurrence of BV, which was defined as 3 of 4 Amsel criteria plus abnormal vaginal discharge/vulvar odor during 4 months of intake of the test dietary supplement. Differences between the groups were assessed with Z test for proportions.

Results: One hundred sixty-six women were analyzed in the verum (82 patients) and the placebo group (82 patients). Recurrence of BV was documented in 15 (18.3%) of 82 women in the verum group and 27 (32.1%) of 84 in the placebo group (p = .014). Rates of survival without BV rates were higher in the verum group (Cox F test, p = .018). Both verum and placebo supplements were well tolerated.

Conclusions: Oral intake of L. crispatus LMG S-29995, L. brevis, and L. acidophilus can significantly decrease percent of recurrences of BV in recently treated women and prolong time to recurrence of the disease.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus brevis VPro 18Reduced Recurrence of Bacterial VaginosisBeneficial
Moderate
Lactobacillus crispatus LBV 88Reduced Recurrence of Bacterial VaginosisBeneficial
Moderate
Lactobacillus crispatus LBV88Increased Survival Without Bacterial VaginosisBeneficial
Moderate
Lactobacillus crispatus LBV88Reduced Recurrence of Bacterial VaginosisBeneficial
Moderate
Lactobacillus crispatus LV5 88Reduced Recurrence of Bacterial VaginosisBeneficial
Moderate
Lactobacillus crispatus VPro 31Increased Survival Without Bacterial VaginosisBeneficial
Moderate
Lactobacillus crispatus VPro 31Reduced Recurrence of Bacterial VaginosisBeneficial
Moderate
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