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Oral probiotic activities and biosafety of Lactobacillus gasseri HHuMIN D

  • 2021-03-23
  • Microbial Cell Factories 20(1)
    • Soyon Mann
    • Myeong-Soo Park
    • Tony V Johnston
    • G. Ji
    • K. Hwang
    • Seockmo Ku

Abstract

Background: Lactobacillus spp. have been researched worldwide and are used in probiotics, but due to difficulties with laboratory cultivation of and experimentation on oral microorganisms, there are few reports of Lactobacillus spp. being isolated from the oral cavity and tested against oral pathogens. This research sought to isolate and determine the safety and inhibitory capabilities of a Lactobacillus culture taken from the human body.

Results: One organism was isolated, named "L. gasseri HHuMIN D", and evaluated for safety. A 5% dilution of L. gasseri HHuMIN D culture supernatant exhibited 88.8% inhibition against halitosis-producing anaerobic microorganisms and the organism itself exhibited powerful inhibitory effects on the growth of 11 oral bacteria. Hydrogen peroxide production reached 802 μmol/L after 12 h and gradually diminished until 24 h, it efficiently aggregated with P. catoniae and S. sanguinis, and it completely suppressed S. mutans-manufactured artificial dental plaque. L. gasseri HHuMIN D's KB cell adhesion capacity was 4.41 cells per cell, and the cell adhesion of F. nucleatum and S. mutans diminished strongly in protection and displacement assays.

Conclusion: These results suggest that L. gasseri HHuMIN D is a safe, bioactive, lactobacterial food ingredient, starter culture, and/or probiotic microorganism for human oral health.

Keywords: Antimicrobial Effect; Biosafety Evaluation; Lactobacillus gasseri; Oral Microorganisms.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus gasseriIncreased Hydrogen Peroxide ProductionBeneficial
Moderate
Lactobacillus gasseriReduced Formation of Dental PlaqueBeneficial
Large
Lactobacillus gasseriReduced HalitosisBeneficial
Large
Lactobacillus gasseriReduced Oral Carriage of Cariogenic PathogensBeneficial
Large
Lactobacillus gasseri KS-13Increased Bacterial AggregationBeneficial
Moderate
Lactobacillus gasseri KS-13Increased Hydrogen Peroxide ProductionBeneficial
Moderate
Lactobacillus gasseri KS-13Reduced Cell AdhesionBeneficial
Moderate
Lactobacillus gasseri KS-13Reduced Formation of Dental PlaqueBeneficial
Large
Lactobacillus gasseri KS-13Reduced HalitosisBeneficial
Large
Lactobacillus gasseri KS-13Reduced Oral Bacteria GrowthBeneficial
Large
Lactobacillus gasseri LAC-343Enhanced Cell Adhesion CapacityBeneficial
Moderate
Lactobacillus gasseri LAC-343Increased Hydrogen Peroxide ProductionBeneficial
Moderate
Lactobacillus gasseri LAC-343Reduced Antimicrobial AggregationBeneficial
Moderate
Lactobacillus gasseri LAC-343Reduced Formation of Dental PlaqueBeneficial
Large
Lactobacillus gasseri LAC-343Reduced HalitosisBeneficial
Large
Lactobacillus gasseri LAC-343Reduced Oral Bacteria GrowthBeneficial
Large
Lactobacillus gasseri LQ-36Enhanced Adhesion Capacity to Oral CellsBeneficial
Moderate
Lactobacillus gasseri LQ-36Increased Bacterial AggregationBeneficial
Moderate
Lactobacillus gasseri LQ-36Increased Hydrogen Peroxide ProductionBeneficial
Moderate
Lactobacillus gasseri LQ-36Reduced Formation of Dental PlaqueBeneficial
Large
Lactobacillus gasseri LQ-36Reduced HalitosisBeneficial
Large
Lactobacillus gasseri LQ-36Reduced Oral Bacteria GrowthBeneficial
Large
Lactobacillus gasseri LQ-36Reduced Pathogenic Bacteria AdhesionBeneficial
Large
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