Panax ginseng and aging related disorders: A systematic review.

2022-05
Experimental gerontology 161
- Bárbara de Oliveira Zanuso
- Ana Rita de Oliveira Dos Santos
- Vitor Fernando Bordin Miola
- Leila M Guissoni Campos
- Caio Sergio Galina Spilla
- Sandra Maria Barbalho

PubMed: 35143871
DOI: 10.1016/j.exger.2022.111731

Study Design

Type: Systematic Review

The aging process predisposes numerous homeostatic disorders, metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancer. Changes in diet and lifestyle and therapeutic adjuvants are essential to minimize the effects of comorbidities associated with aging. Natural products such as Panax ginseng have been used to treat and prevent diseases related to aging. This review aims to investigate the effects of Panax ginseng in various conditions associated with aging, such as inflammation, oxidative stress, mitochondrial dysfunction, apoptosis, neurodegenerative and metabolic disorders, cardiovascular diseases, and cancer. The ginsenosides, chemical constituents found in Panax ginseng, can inhibit the effects of inflammatory cytokines, inhibit signaling pathways that induce inflammation, and inhibit cells that participate in inflammatory processes. Besides, ginsenosides are involved in neuroprotective effects on the central nervous system due to anti-apoptotic, antioxidant, and anti-inflammatory effects. The use of ginseng extract showed actions on lipid homeostasis, positively regulating high-density lipoprotein, down-regulating low-density lipoprotein and triglyceride levels, and producing beneficial effects on vascular endothelial function. The use of this plant in cancer resulted in improved quality of life and mood. It decreased symptoms of fatigue, nausea, vomiting, and dyspnea, reducing anxiety. Panax ginseng has been shown to exert potent therapeutic benefits that can act as a complementary treatment in managing patients with chronic diseases related to aging.

Research Insights

Panax Ginseng→Improved Mood
The use of this plant in cancer resulted in improved quality of life and mood. It decreased symptoms of fatigue, nausea, vomiting, and dyspnea, reducing anxiety.
Effect
Beneficial
Effect size
Small
Panax Ginseng→Improved Quality of Life
The use of this plant in cancer resulted in improved quality of life and mood. It decreased symptoms of fatigue, nausea, vomiting, and dyspnea, reducing anxiety.
Effect
Beneficial
Effect size
Small
Panax Ginseng→Improved Vascular Endothelial Function
The use of ginseng extract showed actions on lipid homeostasis, positively regulating high-density lipoprotein, down-regulating low-density lipoprotein and triglyceride levels, and producing beneficial effects on vascular endothelial function.
Effect
Beneficial
Effect size
Small
Panax Ginseng→Increased HDL Cholesterol Levels
The use of ginseng extract showed actions on lipid homeostasis, positively regulating high-density lipoprotein, down-regulating low-density lipoprotein and triglyceride levels, and producing beneficial effects on vascular endothelial function.
Effect
Beneficial
Effect size
Small
Panax Ginseng→Reduced Anxiety
The use of this plant in cancer resulted in improved quality of life and mood. It decreased symptoms of fatigue, nausea, vomiting, and dyspnea, reducing anxiety.
Effect
Beneficial
Effect size
Small
Panax Ginseng→Reduced Dyspnea
The use of this plant in cancer resulted in improved quality of life and mood. It decreased symptoms of fatigue, nausea, vomiting, and dyspnea, reducing anxiety.
Effect
Beneficial
Effect size
Small
Panax Ginseng→Reduced Fatigue
The use of this plant in cancer resulted in improved quality of life and mood. It decreased symptoms of fatigue, nausea, vomiting, and dyspnea, reducing anxiety.
Effect
Beneficial
Effect size
Small
Panax Ginseng→Reduced Low-Density Lipoprotein Level
The use of ginseng extract showed actions on lipid homeostasis, positively regulating high-density lipoprotein, down-regulating low-density lipoprotein and triglyceride levels, and producing beneficial effects on vascular endothelial function.
Effect
Beneficial
Effect size
Small
Panax Ginseng→Reduced Nausea
The use of this plant in cancer resulted in improved quality of life and mood. It decreased symptoms of fatigue, nausea, vomiting, and dyspnea, reducing anxiety.
Effect
Beneficial
Effect size
Small
Panax Ginseng→Reduced Triglyceride Levels
The use of ginseng extract showed actions on lipid homeostasis, positively regulating high-density lipoprotein, down-regulating low-density lipoprotein and triglyceride levels, and producing beneficial effects on vascular endothelial function.
Effect
Beneficial
Effect size
Small
Panax Ginseng→Reduced Vomiting
The use of this plant in cancer resulted in improved quality of life and mood. It decreased symptoms of fatigue, nausea, vomiting, and dyspnea, reducing anxiety.
Effect
Beneficial
Effect size
Small