Paraprobiotics: definition, manufacturing methods, and functionality.
- 2023-07-17
- Food science and biotechnology 32(14)
- Na-Kyoung Lee
- Young-Seo Park
- Dae-Kyung Kang
- Hyun-Dong Paik
- PubMed: 37860741
- DOI: 10.1007/s10068-023-01378-y
Probiotics are living microorganisms that are beneficial to the host, enhancing the immune response by promoting antibody production, regulating cytokine secretion, and stimulating T cells. However, probiotics have limitations in that they require viability control and have a short shelf life. Recently, the use of paraprobiotics has gained attention. These include dead bacterial cells, bacterial fractions, and cell lysate that have health benefits and are stable and safe for use. Paraprobiotics comprise molecules of bacterial cell wall compounds, such as peptidoglycans, teichoic acids, polysaccharides, and cell surface proteins. Paraprobiotics are manufactured by a diverse range of techniques, including thermal treatments, high pressure, ultraviolet rays, sonication, ionizing radiation, and pH modification. Their beneficial health effects include immunomodulatory, intestinal balancing, anticancer, and antimicrobial activities. Therefore, this review summarizes and discusses the manufacturing methods and bioavailability of paraprobiotics and suggests their potential health advantages.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus brevis SBC8803 | Enhanced Antimicrobial Activity | Beneficial | Small |
| Lactobacillus brevis SBC8803 | Improved Gut Microbiota Balance | Beneficial | Small |
| Lactobacillus brevis SBC8803 | Improved Immune Modulation | Beneficial | Moderate |
| Lactobacillus brevis SBC8803 | Reduced Cancer Cell Growth | Beneficial | Small |